Andrew M McKinney
Overview
Explore the profile of Andrew M McKinney including associated specialties, affiliations and a list of published articles.
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6
Citations
131
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0
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Recent Articles
1.
Kelberman M, Rodberg E, Arabzadeh E, Bair-Marshall C, Berridge C, Berrocoso E, et al.
bioRxiv
. 2024 Oct;
PMID: 39464004
The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as autonomic systems, the...
2.
McKinney A, Mathur R, Stevers N, Molinaro A, Chang S, Phillips J, et al.
Cell Rep
. 2022 Sep;
40(12):111344.
PMID: 36130485
Telomerase activation counteracts senescence and telomere erosion caused by uncontrolled proliferation. Epidermal growth factor receptor (EGFR) amplification drives proliferation while telomerase reverse transcriptase promoter (TERTp) mutations underlie telomerase reactivation through...
3.
Miki S, Koga T, McKinney A, Parisian A, Tadokoro T, Vadla R, et al.
Neuro Oncol
. 2022 Mar;
24(12):2063-2075.
PMID: 35325218
Background: Heterozygous TERT (telomerase reverse transcriptase) promoter mutations (TPMs) facilitate TERT expression and are the most frequent mutation in glioblastoma (GBM). A recent analysis revealed this mutation is one of...
4.
Amen A, Fellmann C, Soczek K, Ren S, Lew R, Knott G, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(13).
PMID: 33758097
Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase () promoter. promoter mutations create a binding site for a GA binding protein (GABP) transcription...
5.
Manjunath M, Yan J, Youn Y, Drucker K, Kollmeyer T, McKinney A, et al.
Neuro Oncol
. 2020 Nov;
23(4):638-649.
PMID: 33130899
Background: Large-scale genome-wide association studies (GWAS) have implicated thousands of germline genetic variants in modulating individuals' risk to various diseases, including cancer. At least 25 risk loci have been identified...
6.
Mancini A, Xavier-Magalhaes A, Woods W, Nguyen K, Amen A, Hayes J, et al.
Cancer Cell
. 2018 Sep;
34(3):513-528.e8.
PMID: 30205050
TERT promoter mutations reactivate telomerase, allowing for indefinite telomere maintenance and enabling cellular immortalization. These mutations specifically recruit the multimeric ETS factor GABP, which can form two functionally independent transcription...