Andrew M Lynn
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Explore the profile of Andrew M Lynn including associated specialties, affiliations and a list of published articles.
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68
Citations
554
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Recent Articles
21.
Singh R, Meena N, Das T, Sharma R, Prakash A, Lynn A
J Biomol Struct Dyn
. 2019 Nov;
38(17):5027-5036.
PMID: 31744390
The funnel shaped energy landscape model of the protein folding suggests that progression of folding proceeds through multiple pathways, having the multiple intermediates which leads to multidimensional free-energy surface. Herein,...
22.
Kumar N, Srivastava R, Prakash A, Lynn A
J Biomol Struct Dyn
. 2019 Aug;
38(11):3396-3410.
PMID: 31422761
The nitrate/nitrite response regulatory protein NarL belongs to the two-component regulatory system of (MTB), plays a crucial role in anaerobic survival of mycobacteria in host. The absence of this protein...
23.
Wasi M, Khandelwal N, Moorhouse A, Nair R, Vishwakarma P, Bravo Ruiz G, et al.
Front Microbiol
. 2019 Aug;
10:1445.
PMID: 31379756
ATP-binding cassette (ABC) superfamily members have a key role as nutrient importers and exporters in bacteria. However, their role as drug exporters in eukaryotes brought this superfamily member to even...
24.
Agarwal V, Naskar P, Agasti S, Khurana G, Vishwakarma P, Lynn A, et al.
Biochim Biophys Acta Mol Cell Res
. 2019 Jul;
1866(10):1618-1633.
PMID: 31260699
Synaptosomal-associated protein of 23 kDa (SNAP-23) plays an important role during regulated exocytosis of various inflammatory mediators, stored in secretory granules, from mast cells in response to physiological triggers. It...
25.
Kumar V, Pandey P, Idrees D, Prakash A, Lynn A
Biophys Chem
. 2019 Apr;
250:106174.
PMID: 31035038
The structural integrity of N-terminal domain (NTD) of TAR DNA-binding protein-43 (TDP-43) is essential for the biological functions of TDP-43 involved in neurodegenerative diseases. Here, we used all-atom molecular dynamics...
26.
Pandey P, Meena N, Prakash A, Kumar V, Lynn A, Ahmad F
J Biomol Struct Dyn
. 2019 Mar;
38(4):1042-1053.
PMID: 30880641
Folding pathway of β-LgA (β-lactoglobulin) evolves through the conformational α→β transition. The α→β transition is a molecular hallmark of various neurodegenerative diseases. Thus, β-LgA may serve as a good model...
27.
Bharti D, Hemrom A, Lynn A
BMC Bioinformatics
. 2019 Feb;
19(Suppl 13):550.
PMID: 30717669
Background: Traditional drug discovery approaches are time-consuming, tedious and expensive. Identifying a potential drug-like molecule using high throughput screening (HTS) with high confidence is always a challenging task in drug...
28.
Banerjee A, Vishwakarma P, Kumar A, Lynn A, Prasad R
Arch Biochem Biophys
. 2019 Jan;
663:143-150.
PMID: 30653962
ABC transporters are membrane-bound pumps composed of two major domains: the transmembrane domain(s) (TMDs) and the nucleotide-binding domain(s) (NBDs). Sequence analyses of the NBDs of key ABC exporters revealed a...
29.
Vishwakarma P, Banerjee A, Pasrija R, Prasad R, Lynn A
Int J Biol Macromol
. 2019 Jan;
127:95-106.
PMID: 30639597
ABC transporter proteins are involved in active transport, both in prokaryotes and eukaryotes. Sequence analysis of nucleotide binding domains (NBDs) of ABC proteins from all taxa revealed a well-conserved new...
30.
Gupta S, Lynn A, Gupta V
3 Biotech
. 2018 Dec;
8(12):504.
PMID: 30555765
Structure-based drug discovery has emerged as a powerful tool in computational drug discovery and has gained rapid acceleration due to the development of better algorithms for high-end computation in an...