Andrew J Spakowitz
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Explore the profile of Andrew J Spakowitz including associated specialties, affiliations and a list of published articles.
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71
Citations
1339
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Recent Articles
1.
Tse A, Spakowitz A
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2415530121.
PMID: 39792289
DNA methylation is a crucial epigenetic modification that orchestrates chromatin remodelers that suppress transcription, and aberrations in DNA methylation result in a variety of conditions such as cancers and developmental...
2.
Burgener E, Cai P, Kratochvil M, Rojas-Hernandez L, Joo N, Gupta A, et al.
PNAS Nexus
. 2024 Sep;
3(9):pgae390.
PMID: 39301510
is a major pulmonary pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF). The and lysogenic bacteriophage, Pf phage, is abundant in the airways of many people with...
3.
Clerkin A, Pagane N, West D, Spakowitz A, Risca V
bioRxiv
. 2024 Aug;
PMID: 39131347
The three-dimensional structure of chromatin has emerged as an important feature of eukaryotic gene regulation. Recent technological advances in DNA sequencing-based assays have revealed locus- and chromatin state-specific structural patterns...
4.
Wakim J, Spakowitz A
Proc Natl Acad Sci U S A
. 2024 Jun;
121(26):e2317911121.
PMID: 38900792
Euchromatin is an accessible phase of genetic material containing genes that encode proteins with increased expression levels. The structure of euchromatin in vitro has been described as a 30-nm fiber...
5.
Ghosh A, Spakowitz A
Soft Matter
. 2024 Jun;
20(32):6332-6342.
PMID: 38881306
Large-scale cellular transformations are triggered by subtle physical and structural changes to individual biomacromolecular and membrane components. A prototypical example of such an event is the orchestrated fusion of membranes...
6.
Cai P, Braunreuther M, Shih A, Spakowitz A, Fuller G, Heilshorn S
APL Bioeng
. 2024 May;
8(2):026112.
PMID: 38721267
Intestinal health heavily depends on establishing a mucus layer within the gut with physical properties that strike a balance between being sufficiently elastic to keep out harmful pathogens yet viscous...
7.
Dutta S, Ghosh A, Spakowitz A
Soft Matter
. 2024 Jan;
20(8):1694-1701.
PMID: 38226903
Active fluctuations play a significant role in the structure and dynamics of biopolymers ( chromatin and cytoskeletal proteins) that are instrumental in the functioning of living cells. For a large...
8.
Dutta S, Ghosh A, Boettiger A, Spakowitz A
Biophys J
. 2023 Aug;
122(17):3532-3540.
PMID: 37542372
Chromosomal dynamics plays a central role in a number of critical biological processes, such as transcriptional regulation, genetic recombination, and DNA replication. However, visualization of chromatin is generally limited to...
9.
Balhorn L, MacPherson Q, Bustillo K, Takacs C, Spakowitz A, Salleo A
Proc Natl Acad Sci U S A
. 2022 Nov;
119(46):e2204346119.
PMID: 36343237
A grand challenge in materials science is to identify the impact of molecular composition and structure across a range of length scales on macroscopic properties. We demonstrate a unified experimental-theoretical...
10.
Ghosh A, MacPherson Q, Wang Z, Spakowitz A
J Chem Phys
. 2022 Oct;
157(15):154906.
PMID: 36272793
We study the collective elastic behavior of semiflexible polymer solutions in a nematic liquid-crystalline state using polymer field theory. Our polymer field-theoretic model of semiflexible polymer solutions is extended to...