Andrew J Sedgewick
Overview
Explore the profile of Andrew J Sedgewick including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
363
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0
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Recent Articles
1.
Van Loon K, Mmbaga E, Mushi B, Selekwa M, Mwanga A, Akoko L, et al.
Cancer Epidemiol Biomarkers Prev
. 2023 Jul;
32(10):1411-1420.
PMID: 37505926
Background: Esophageal squamous cell carcinoma (ESCC) comprises 90% of all esophageal cancer cases globally and is the most common histology in low-resource settings. Eastern Africa has a disproportionately high incidence...
2.
Leibowitz B, Dougherty B, Bell J, Kapilivsky J, Michuda J, Sedgewick A, et al.
BMC Cancer
. 2022 Jun;
22(1):587.
PMID: 35643464
Background: With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types....
3.
Liu Y, Cook C, Sedgewick A, Zhang S, Fassett M, Ricardo-Gonzalez R, et al.
iScience
. 2020 Nov;
23(10):101582.
PMID: 33205009
Inflammatory response heterogeneity has impeded high-resolution dissection of diverse immune cell populations during activation. We characterize mouse cutaneous immune cells by single-cell RNA sequencing, after inducing inflammation using imiquimod and...
4.
Newton Y, Sedgewick A, Cisneros L, Golovato J, Johnson M, Szeto C, et al.
Sci Rep
. 2020 Oct;
10(1):17597.
PMID: 33077815
Transcriptome profiling can provide information of great value in clinical decision-making, yet RNA from readily available formalin-fixed paraffin-embedded (FFPE) tissue is often too degraded for quality sequencing. To assess the...
5.
Abecassis I, Sedgewick A, Romkes M, Buch S, Nukui T, Kapetanaki M, et al.
Sci Rep
. 2019 Mar;
9(1):3309.
PMID: 30824778
Personalized cancer therapy relies on identifying patient subsets that benefit from a therapeutic intervention and suggest alternative regimens for those who don't. A new data integrative approach, based on graphical...
6.
Harirchian P, Lee J, Hilz S, Sedgewick A, Perez White B, Kesling M, et al.
J Invest Dermatol
. 2018 Dec;
139(6):1264-1273.
PMID: 30543901
Genetic variation in the NF-κB inhibitors, ABIN1 and A20, increase risk for psoriasis. While critical for hematopoietic immune cell function, these genes are believed to additionally inhibit psoriasis by dampening...
7.
Kim Y, Sweet S, Egertson J, Sedgewick A, Woo S, Liao W, et al.
J Proteome Res
. 2018 Nov;
18(1):426-435.
PMID: 30481034
Mass spectrometry-based protein quantitation is currently used to measure therapeutically relevant protein biomarkers in CAP/CLIA setting to predict likely responses of known therapies. Selected reaction monitoring (SRM) is the method...
8.
Cheng J, Sedgewick A, Finnegan A, Harirchian P, Lee J, Kwon S, et al.
Cell Rep
. 2018 Oct;
25(4):871-883.
PMID: 30355494
Perturbations in the transcriptional programs specifying epidermal differentiation cause diverse skin pathologies ranging from impaired barrier function to inflammatory skin disease. However, the global scope and organization of this complex...
9.
Caparosa E, Sedgewick A, Zenonos G, Zhao Y, Carlisle D, Stefaneanu L, et al.
Neurosurgery
. 2018 Oct;
85(2):E284-E293.
PMID: 30335165
Background: Many studies have explored molecular markers of carotid plaque development and vulnerability to rupture, usually having examined whole carotid plaques. However, there are regional differences in plaque morphology and...
10.
Sedgewick A, Buschur K, Shi I, Ramsey J, Raghu V, Manatakis D, et al.
Bioinformatics
. 2018 Sep;
35(7):1204-1212.
PMID: 30192904
Motivation: Integration of data from different modalities is a necessary step for multi-scale data analysis in many fields, including biomedical research and systems biology. Directed graphical models offer an attractive...