Andrew J Leger
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Explore the profile of Andrew J Leger including associated specialties, affiliations and a list of published articles.
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13
Citations
973
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Recent Articles
1.
Zhang P, Leger A, Baleja J, Rana R, Corlin T, Nguyen N, et al.
J Biol Chem
. 2015 May;
290(25):15785-15798.
PMID: 25934391
G protein-coupled receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number of different agonists on the outside of the cell. However, the inside surface of...
2.
Clayton N, Nelson C, Weeden T, Taylor K, Moreland R, Scheule R, et al.
Mol Ther Nucleic Acids
. 2014 Oct;
3:e206.
PMID: 25350581
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles....
3.
Leger A, Mosquea L, Clayton N, Wu I, Weeden T, Nelson C, et al.
Nucleic Acid Ther
. 2013 Jan;
23(2):109-17.
PMID: 23308382
Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic RNA gain-of-function that leads to detrimental changes in RNA metabolism. A CTG repeat element normally resides in...
4.
Wheeler T, Leger A, Pandey S, MacLeod A, Nakamori M, Cheng S, et al.
Nature
. 2012 Aug;
488(7409):111-5.
PMID: 22859208
Antisense oligonucleotides (ASOs) hold promise for gene-specific knockdown in diseases that involve RNA or protein gain-of-function effects. In the hereditary degenerative disease myotonic dystrophy type 1 (DM1), transcripts from the...
5.
Leger A, Mosquea L, Li L, Chuang W, Pacheco J, Taylor K, et al.
J Gene Med
. 2011 Jun;
13(6):324-32.
PMID: 21674735
Background: The secretory form of acid sphingomyelinase (ASM) is postulated to play a key role in the retention and aggregation of lipoproteins in the subendothelial space of the arterial wall...
6.
Leger A, Altobelli A, Mosquea L, Belanger A, Song A, Cheng S, et al.
J Bone Miner Metab
. 2010 Mar;
28(5):510-9.
PMID: 20300790
Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and resorption activity have been shown to be enhanced in the presence...
7.
Trivedi V, Boire A, Tchernychev B, Kaneider N, Leger A, OCallaghan K, et al.
Cell
. 2009 Apr;
137(2):332-43.
PMID: 19379698
Matrix metalloproteases (MMPs) play important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation, angiogenesis, and cancer. MMPs have been viewed as matrix-degrading enzymes, but recent studies have...
8.
Kaneider N, Leger A, Agarwal A, Nguyen N, Perides G, Derian C, et al.
Nat Immunol
. 2007 Oct;
8(12):1303-12.
PMID: 17965715
Sepsis is a deadly disease characterized by considerable derangement of the proinflammatory, anti-inflammatory and coagulation responses. Protease-activated receptor 1 (PAR1), an important regulator of endothelial barrier function and blood coagulation,...
9.
Kaneider N, Leger A, Kuliopulos A
FEBS J
. 2006 Sep;
273(19):4416-24.
PMID: 16956369
Inflammation is traditionally viewed as a physiological reaction to tissue injury. Leukocytes contribute to the inflammatory response by the secretion of cytotoxic and pro-inflammatory compounds, by phagocytotic activity and by...
10.
Leger A, Covic L, Kuliopulos A
Circulation
. 2006 Sep;
114(10):1070-7.
PMID: 16952995
Thrombosis associated with the pathophysiological activation of platelets and vascular cells has brought thrombin and its receptors to the forefront of cardiovascular medicine. Thrombin signaling through the protease-activated receptors (PARs)...