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Andrew J Capel

Explore the profile of Andrew J Capel including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 198
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Recent Articles
1.
Fernandez-Rhodes M, Buchan E, Gagnon S, Qian J, Gethings L, Lees R, et al.
J Extracell Biol . 2024 Aug; 3(8):e171. PMID: 39169919
Skeletal muscle (SM) acts as a secretory organ, capable of releasing myokines and extracellular vesicles (SM-EVs) that impact myogenesis and homeostasis. While age-related changes have been previously reported in murine...
2.
Capel A, Smith M, Taccola S, Pardo-Figuerez M, Rimington R, Lewis M, et al.
Front Cell Dev Biol . 2021 Sep; 9:722294. PMID: 34527674
Digitally driven manufacturing technologies such as aerosol jet printing (AJP) can make a significant contribution to enabling new capabilities in the field of tissue engineering disease modeling and drug screening....
3.
Rimington R, Fleming J, Capel A, Wheeler P, Lewis M
Sci Rep . 2021 Jun; 11(1):11695. PMID: 34083648
Investigations of the human neuromuscular junction (NMJ) have predominately utilised experimental animals, model organisms, or monolayer cell cultures that fail to represent the physiological complexity of the synapse. Consequently, there...
4.
Turner M, Rimington R, Martin N, Fleming J, Capel A, Hodson L, et al.
J Cell Physiol . 2021 Mar; 236(10):7033-7044. PMID: 33738797
Fatty acids (FA) exert physiological and pathophysiological effects leading to changes in skeletal muscle metabolism and function, however, in vitro models to investigate these changes are limited. These experiments sought...
5.
Rimington R, Capel A, Chaplin K, Fleming J, Hemaka Bandulasena H, Bibb R, et al.
ACS Biomater Sci Eng . 2021 Jan; 5(10):5525-5538. PMID: 33464072
Bioengineered skeletal muscle tissues benefit from dynamic culture environments which facilitate the appropriate provision of nutrients and removal of cellular waste products. Biologically compatible perfusion systems hold the potential to...
6.
Pardo-Figuerez M, Martin N, Player D, Capel A, Christie S, Lewis M
ACS Biomater Sci Eng . 2021 Jan; 4(1):98-106. PMID: 33418681
The disordered environment found in conventional neural cultures impedes various applications where cell directionality is a key process for functionality. Neurons are highly specialized cells known to be greatly dependent...
7.
Aguilar-Agon K, Capel A, Fleming J, Player D, Martin N, Lewis M
J Muscle Res Cell Motil . 2020 Sep; 42(2):149-159. PMID: 32955689
Skeletal muscle atrophy as a consequence of acute and chronic illness, immobilisation, muscular dystrophies and aging, leads to severe muscle weakness, inactivity and increased mortality. Mechanical loading is thought to...
8.
Fleming J, Capel A, Rimington R, Player D, Stolzing A, Lewis M
Cytoskeleton (Hoboken) . 2019 Aug; 76(6):371-382. PMID: 31376315
Skeletal muscle has a high regenerative capacity, injuries trigger a regenerative program which restores tissue function to a level indistinguishable to the pre-injury state. However, in some cases where significant...
9.
Aguilar-Agon K, Capel A, Martin N, Player D, Lewis M
J Cell Physiol . 2019 Jun; 234(12):23547-23558. PMID: 31180593
Mechanical loading of skeletal muscle results in molecular and phenotypic adaptations typified by enhanced muscle size. Studies on humans are limited by the need for repeated sampling, and studies on...
10.
Capel A, Rimington R, Fleming J, Player D, Baker L, Turner M, et al.
Front Bioeng Biotechnol . 2019 Mar; 7:20. PMID: 30838203
Tissue engineered skeletal muscle allows investigation of the cellular and molecular mechanisms that regulate skeletal muscle pathology. The fabricated model must resemble characteristics of tissue and incorporate cost-effective and high...