Jacob W Fleming
Overview
Explore the profile of Jacob W Fleming including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
92
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Recent Articles
1.
Fleming J, McCloskey M, Gray K, Nash D, Leung V, Michas C, et al.
Curr Res Toxicol
. 2025 Feb;
8:100218.
PMID: 39944108
Animal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling. Challenges with scarcity, scalability, throughput,...
2.
Beall D, Davis T, Amirdelfan K, Naidu R, DePalma M, Costandi S, et al.
Pain Physician
. 2024 Dec;
27(8):E865-E871.
PMID: 39621986
Background: Preventing disc degeneration remains a clinical challenge; patients experiencing chronic lumbar discogenic pain have limited treatment options. Minimally invasive intradiscal procedures such as allogeneic nucleus pulposus (NP) injection have...
3.
Fleming J, Pan T, AbuBakar M, Shonnard M, Radlicz C, Beall D
Tech Vasc Interv Radiol
. 2024 Nov;
27(3):100984.
PMID: 39490375
The sacroiliac joint (SIJ) is the largest diarthrodial joint in the human body and accounts for approximately 20% of all low back pain, which is commonly seen in patients with...
4.
Dalili D, Holzwanger D, Fleming J, Igbinoba Z, Dalili D, Beall D, et al.
Semin Musculoskelet Radiol
. 2024 May;
28(3):267-281.
PMID: 38768592
The prevalence of knee osteoarthritis (OA) is the highest among all joints and likely to increase over the coming decades. Advances in the repertoire of diagnostic capabilities of imaging and...
5.
Smith A, Luttrell S, Dupont J, Gray K, Lih D, Fleming J, et al.
J Tissue Eng
. 2022 Sep;
13:20417314221122127.
PMID: 36082311
Engineered muscle tissues represent powerful tools for examining tissue level contractile properties of skeletal muscle. However, limitations in the throughput associated with standard analysis methods limit their utility for longitudinal...
6.
Rimington R, Fleming J, Capel A, Wheeler P, Lewis M
Sci Rep
. 2021 Jun;
11(1):11695.
PMID: 34083648
Investigations of the human neuromuscular junction (NMJ) have predominately utilised experimental animals, model organisms, or monolayer cell cultures that fail to represent the physiological complexity of the synapse. Consequently, there...
7.
Turner M, Rimington R, Martin N, Fleming J, Capel A, Hodson L, et al.
J Cell Physiol
. 2021 Mar;
236(10):7033-7044.
PMID: 33738797
Fatty acids (FA) exert physiological and pathophysiological effects leading to changes in skeletal muscle metabolism and function, however, in vitro models to investigate these changes are limited. These experiments sought...
8.
Rimington R, Capel A, Chaplin K, Fleming J, Hemaka Bandulasena H, Bibb R, et al.
ACS Biomater Sci Eng
. 2021 Jan;
5(10):5525-5538.
PMID: 33464072
Bioengineered skeletal muscle tissues benefit from dynamic culture environments which facilitate the appropriate provision of nutrients and removal of cellular waste products. Biologically compatible perfusion systems hold the potential to...
9.
Aguilar-Agon K, Capel A, Fleming J, Player D, Martin N, Lewis M
J Muscle Res Cell Motil
. 2020 Sep;
42(2):149-159.
PMID: 32955689
Skeletal muscle atrophy as a consequence of acute and chronic illness, immobilisation, muscular dystrophies and aging, leads to severe muscle weakness, inactivity and increased mortality. Mechanical loading is thought to...
10.
Mandel J, Makary M, Fleming J, Duncan D, Gutta N, Noor M, et al.
J Vasc Interv Radiol
. 2019 Nov;
31(1):176-178.
PMID: 31771891
No abstract available.