Andrew Hercules
Overview
Explore the profile of Andrew Hercules including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
1040
Followers
0
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Related Specialties
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Recent Articles
1.
Ochoa D, Hercules A, Carmona M, Suveges D, Baker J, Malangone C, et al.
Nucleic Acids Res
. 2022 Nov;
51(D1):D1353-D1359.
PMID: 36399499
The Open Targets Platform (https://platform.opentargets.org/) is an open source resource to systematically assist drug target identification and prioritisation using publicly available data. Since our last update, we have reimagined, redesigned,...
2.
Mountjoy E, Schmidt E, Carmona M, Schwartzentruber J, Peat G, Miranda A, et al.
Nat Genet
. 2021 Oct;
53(11):1527-1533.
PMID: 34711957
Genome-wide association studies (GWASs) have identified many variants associated with complex traits, but identifying the causal gene(s) is a major challenge. In the present study, we present an open resource...
3.
Schneider M, Radoux C, Hercules A, Ochoa D, Dunham I, Zalmas L, et al.
Nat Rev Drug Discov
. 2021 Jul;
20(10):789-797.
PMID: 34285415
Proteolysis-targeting chimeras (PROTACs) are an emerging drug modality that may offer new opportunities to circumvent some of the limitations associated with traditional small-molecule therapeutics. By analogy with the concept of...
4.
Ochoa D, Hercules A, Carmona M, Suveges D, Gonzalez-Uriarte A, Malangone C, et al.
Nucleic Acids Res
. 2020 Nov;
49(D1):D1302-D1310.
PMID: 33196847
The Open Targets Platform (https://www.targetvalidation.org/) provides users with a queryable knowledgebase and user interface to aid systematic target identification and prioritisation for drug discovery based upon underlying evidence. It is...
5.
Ghoussaini M, Mountjoy E, Carmona M, Peat G, Schmidt E, Hercules A, et al.
Nucleic Acids Res
. 2020 Oct;
49(D1):D1311-D1320.
PMID: 33045747
Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction and conformation data from a wide...
6.
Carvalho-Silva D, Pierleoni A, Pignatelli M, Ong C, Fumis L, Karamanis N, et al.
Nucleic Acids Res
. 2018 Nov;
47(D1):D1056-D1065.
PMID: 30462303
The Open Targets Platform integrates evidence from genetics, genomics, transcriptomics, drugs, animal models and scientific literature to score and rank target-disease associations for drug target identification. The associations are displayed...