Andrew Hemphill

Overview

Explore the profile of Andrew Hemphill including associated specialties, affiliations and a list of published articles.

Snapshot

Articles 241

Citations 3330

Followers 0

Related Specialties

Parasitology

Pharmacology

Infectious Diseases

Top 10 Co-Authors

Joachim Muller

Norbert Muller

Bruno Gottstein

Wesley C Van Voorhis

Ghalia Boubaker

Kayode K Ojo

Dennis Imhof

Nicoleta Anghel

Arunasalam Naguleswaran

Vreni Balmer

Published In

Antimicrob Agents Chemother

Int J Parasitol

Exp Parasitol

Int J Parasitol Drugs Drug Resist

Parasitology

Affiliations

Soon will be listed here.

Recent Articles

11.

TaqMan-quantitative PCR assays applied in knock-outs generated through CRISPR-Cas9 allow to determine the copy numbers of integrated dihydrofolate reductase-thymidylate synthase

Rico-San Roman L, Hanggeli K, Hemphill A, Horcajo P, Collantes-Fernandez E, Ortega-Mora L, et al.

Front Cell Infect Microbiol . 2024 Jul; 14:1419209. PMID: 38975328

As for many other organisms, CRISPR-Cas9 mediated genetic modification has gained increasing importance for the identification of vaccine candidates and drug targets in , an apicomplexan parasite causing abortion in...

12.

Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice

de Sousa M, Imhof D, Hanggeli K, Choi R, Hulverson M, Arnold S, et al.

Int J Parasitol Drugs Drug Resist . 2024 Jun; 25:100553. PMID: 38917582

Toxoplasma gondii and Neospora caninum are major worldwide morbidity-causing pathogens. Bumped kinase inhibitors (BKIs) are a compound class that has been optimized to target the apicomplexan calcium-dependent protein kinase 1...

13.

Working towards the development of vaccines and chemotherapeutics against neosporosis-With all of its ups and downs-Looking ahead

Imhof D, Hanggeli K, de Sousa M, Vigneswaran A, Hofmann L, Amdouni Y, et al.

Adv Parasitol . 2024 May; 124:91-154. PMID: 38754928

Neospora caninum is an apicomplexan and obligatory intracellular parasite, which is the leading cause of reproductive failure in cattle and affects other farm and domestic animals, but also induces neuromuscular...

14.

In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii

Boubaker G, Bernal A, Vigneswaran A, Imhof D, de Sousa M, Hanggeli K, et al.

Int J Parasitol Drugs Drug Resist . 2024 May; 25:100544. PMID: 38703737

Organometallic compounds, including Ruthenium complexes, have been widely developed as anti-cancer chemotherapeutics, but have also attracted much interest as potential anti-parasitic drugs. Recently hybrid drugs composed of organometallic Ruthenium moieties...

15.

Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in and HCT-8 Host Cells

Ajiboye J, Uldry A, Heller M, Naguleswaran A, Fan E, Van Voorhis W, et al.

Int J Mol Sci . 2024 Mar; 25(5). PMID: 38473953

is an apicomplexan parasite causing persistent diarrhea in humans and animals. Issuing from target-based drug development, calcium-dependent protein kinase 1 inhibitors, collectively named bumped kinase inhibitors (BKIs), with excellent efficacies...

16.

Detection of , , , and sp. nov. in carcasses affected by bovine eosinophilic myositis

Rubiola S, More G, Civera T, Hemphill A, Frey C, Basso W, et al.

Food Waterborne Parasitol . 2024 Feb; 34:e00220. PMID: 38313347

Bovine eosinophilic myositis is an inflammatory myopathy characterized by multiple focal or diffuse grey to green patches leading to condemnation of affected carcasses. Although its etiology is still uncertain, there...

17.

In Vitro Activities of Dithiocarbamate Derivatives against Metacestode Vesicles

Kaethner M, Rennar G, Gallinger T, Kampfer T, Hemphill A, Mader P, et al.

Trop Med Infect Dis . 2023 Dec; 8(12). PMID: 38133449

The metacestode stage of the fox tapeworm causes the severe zoonotic disease alveolar echinococcosis. New treatment options are urgently needed. Disulfiram and dithiocarbamates were previously shown to exhibit activity against...

18.

Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice

Schlange C, Muller J, Imhof D, Hanggeli K, Boubaker G, Ortega-Mora L, et al.

Exp Parasitol . 2023 Nov; 255:108655. PMID: 37981259

In previous studies, the artemisinin derivatives artemisone, its pro-drug artemiside and the bumped-kinase inhibitor BKI-1748 were effective against T. gondii via different modes of action. This suggests that they may...

19.

In vitro screening technologies for the discovery and development of novel drugs against

Muller J, Hemphill A

Expert Opin Drug Discov . 2023 Nov; 19(1):97-109. PMID: 37921660

Introduction: Toxoplasmosis constitutes a challenge for public health, animal production and welfare. Since more than 60 years, only a limited panel of drugs has been in use for clinical applications....

20.

An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii

Sanchez-Sanchez R, Imhof D, Hecker Y, Ferre I, Re M, Moreno-Gonzalo J, et al.

J Infect Dis . 2023 Oct; 229(2):558-566. PMID: 37889572

Congenital toxoplasmosis in humans and in other mammalian species, such as small ruminants, is a well-known cause of abortion and fetal malformations. The calcium-dependent protein kinase 1 (CDPK1) inhibitor BKI-1748...