Andrew B Gladden
Overview
Explore the profile of Andrew B Gladden including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
893
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0
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Recent Articles
1.
The Combined Effects of Urine Zinc, Cadmium, Mercury, Lead, and Copper on Endometrial Cancer Staging
Haruna I, Broaddus R, Gladden A, Subedi K, Obeng-Gyasi E
Int J Environ Res Public Health
. 2025 Feb;
22(2).
PMID: 40003471
Endometrial cancer (EC) is a growing public health concern. This secondary data study of a case series leveraged existing samples and data to explore the potential link between exposure to...
2.
Sahoo S, Ramanand S, Cuevas I, Gao Y, Lee S, Abbas A, et al.
bioRxiv
. 2025 Jan;
PMID: 39763775
One Sentence Summary: We demonstrate that PAX2 is silenced by a highly recurrent epigenetic mechanism to initiate most endometrial cancers, establishing a novel mechanism of tumor suppressor inactivation.
3.
Parrish M, Broaddus R, Gladden A
Front Oncol
. 2022 Oct;
12:1009345.
PMID: 36248967
Endometrial carcinoma (EC) is the most diagnosed gynecological malignancy in Western countries. Both incidence and mortality rates of EC have steadily risen in recent years. Despite generally favorable prognoses for...
4.
Krneta-Stankic V, Corkins M, Paulucci-Holthauzen A, Kloc M, Gladden A, Miller R
Cell Rep
. 2021 Jul;
36(1):109340.
PMID: 34233186
E-cadherin junctions facilitate assembly and disassembly of cell contacts that drive development and homeostasis of epithelial tissues. In this study, using Xenopus embryonic kidney and Madin-Darby canine kidney (MDCK) cells,...
5.
Corkins M, Krneta-Stankic V, Kloc M, McCrea P, Gladden A, Miller R
PLoS One
. 2019 Aug;
14(8):e0221698.
PMID: 31469868
Kidneys are composed of numerous ciliated epithelial tubules called nephrons. Each nephron functions to reabsorb nutrients and concentrate waste products into urine. Defects in primary cilia are associated with abnormal...
6.
Lopez E, Vue Z, Broaddus R, Behringer R, Gladden A
Dev Biol
. 2018 Aug;
442(2):301-314.
PMID: 30118662
Disruption of endometrial gland formation or function can cause female infertility. Formation of endometrial glands via tubulogenesis of luminal epithelial cells requires the establishment and maintenance of cell polarity and...
7.
Williams E, Villar-Prados A, Bowser J, Broaddus R, Gladden A
PLoS One
. 2017 Dec;
12(12):e0189081.
PMID: 29206870
Cell adhesion and apicobasal polarity together maintain epithelial tissue organization and homeostasis. Loss of adhesion has been described as a prerequisite for the epithelial to mesenchymal transition. However, what role...
8.
Yang C, Graves H, Moya I, Tao C, Hamaratoglu F, Gladden A, et al.
Proc Natl Acad Sci U S A
. 2015 Jan;
112(6):1785-90.
PMID: 25624491
Adherens junctions (AJs) and cell polarity complexes are key players in the establishment and maintenance of apical-basal cell polarity. Loss of AJs or basolateral polarity components promotes tumor formation and...
9.
Hebert A, DuBoff B, Casaletto J, Gladden A, McClatchey A
Genes Dev
. 2012 Dec;
26(24):2709-23.
PMID: 23249734
The ability to generate asymmetry at the cell cortex underlies cell polarization and asymmetric cell division. Here we demonstrate a novel role for the tumor suppressor Merlin and closely related...
10.
Gladden A, Hebert A, Schneeberger E, McClatchey A
Dev Cell
. 2010 Nov;
19(5):727-39.
PMID: 21074722
The neurofibromatosis type 2 (NF2) tumor suppressor, Merlin, is a FERM (Four point one, Ezrin, Radixin, Moesin) domain-containing protein whose loss results in defective morphogenesis and tumorigenesis in multiple tissues....