Andreas Simons
Overview
Explore the profile of Andreas Simons including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
249
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0
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Recent Articles
1.
Treiber C, Simons A, Multhaup G
Biochemistry
. 2006 May;
45(21):6674-80.
PMID: 16716078
The prion protein (PrP) is the key protein implicated in diseases known as transmissible spongiform encephalopathies. PrP has been shown to bind manganese and copper, the latter being involved in...
2.
Egli D, Yepiskoposyan H, Selvaraj A, Balamurugan K, Rajaram R, Simons A, et al.
Mol Cell Biol
. 2006 Mar;
26(6):2286-96.
PMID: 16508004
Metallothioneins are ubiquitous, small, cysteine-rich proteins with the ability to bind heavy metals. In spite of their biochemical characterization, their in vivo function remains elusive. Here, we report the generation...
3.
Pajonk F, Kessler H, Supprian T, Hamzei P, Bach D, Schweickhardt J, et al.
J Alzheimers Dis
. 2005 Sep;
8(1):23-7.
PMID: 16155346
Alzheimer's disease (AD) is a devastating brain disorder clinically characterised by progressive loss of characteristic cognitive abilities. Increasing evidence suggests a disturbed copper (Cu) homeostasis to be associated with the...
4.
Treiber C, Simons A, Strauss M, Hafner M, Cappai R, Bayer T, et al.
J Biol Chem
. 2004 Oct;
279(50):51958-64.
PMID: 15465814
The key protein in Alzheimer's disease, the amyloid precursor protein (APP), is a ubiquitously expressed copper-binding glycoprotein that gives rise to the Abeta amyloid peptide. Whereas overexpression of APP results...
5.
Bayer T, Schafer S, Simons A, Kemmling A, Kamer T, Tepest R, et al.
Proc Natl Acad Sci U S A
. 2003 Nov;
100(24):14187-92.
PMID: 14617773
The Cu-binding beta-amyloid precursor protein (APP), and the amyloid Abeta peptide have been proposed to play a role in physiological metal regulation. There is accumulating evidence of an unbalanced Cu...
6.
Simons A, Ruppert T, Schmidt C, Schlicksupp A, Pipkorn R, Reed J, et al.
Biochemistry
. 2002 Jul;
41(30):9310-20.
PMID: 12135352
The amyloid precursor protein (APP) copper-binding domain (CuBD) has been shown to reduce Cu(II) to Cu(I) and to mediate copper-induced oxidation in vitro. However, little is known about copper binding...
7.
Multhaup G, Scheuermann S, Schlicksupp A, Simons A, Strauss M, Kemmling A, et al.
Free Radic Biol Med
. 2002 Jun;
33(1):45-51.
PMID: 12086681
Oxidative stress was presented to play an important role in the pathogenesis of Alzheimer's disease (AD), especially in the early evolution of AD amyloidogenesis and not only as a consequence...