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Andreas Muhlemann

Explore the profile of Andreas Muhlemann including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 176
Followers 0
Related Specialties
Pharmacology
Chemistry
Neurology
Top 10 Co-Authors
Richard H P Porter
Pari Malherbe
Christophe Fischer
Georg Jaeschke
Martin Stahl
Andy Stucki
Nicole Kratochwil
Catherine Diener
Paul R Gerber
Silvia Gatti
Published In
Br J Pharmacol
Eur J Pharmacol
J Pharmacol Exp Ther
J Neurochem
J Chem Inf Model
Affiliations
Soon will be listed here.
Recent Articles
1.
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP
Malherbe P, Kratochwil N, Muhlemann A, Zenner M, Fischer C, Stahl M, et al.
J Neurochem . 2006 Jun; 98(2):601-15. PMID: 16805850
Fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea], a clinically validated non-benzodiazepine anxiolytic, has been shown to be a potent and non-competitive metabotropic glutamate (mGlu)-5 receptor antagonist. In the present study, we have used the site-directed...
2.
Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors
Muhlemann A, Ward N, Kratochwil N, Diener C, Fischer C, Stucki A, et al.
Eur J Pharmacol . 2005 Dec; 529(1-3):95-104. PMID: 16352303
Several mutations in the seven-transmembrane region of rat metabotropic glutamate 5 (rmGlu5) receptors were produced by site-directed mutagenesis and expressed in CHO cells. Using functional intracellular calcium ([Ca(2+)](i)) mobilisation, we...
3.
An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application
Kratochwil N, Malherbe P, Lindemann L, Ebeling M, Hoener M, Muhlemann A, et al.
J Chem Inf Model . 2005 Sep; 45(5):1324-36. PMID: 16180909
G protein-coupled receptors (GPCRs) share a common architecture consisting of seven transmembrane (TM) domains. Various lines of evidence suggest that this fold provides a generic binding pocket within the TM...
4.
Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity
Porter R, Jaeschke G, Spooren W, Ballard T, Buttelmann B, Kolczewski S, et al.
J Pharmacol Exp Ther . 2005 Jul; 315(2):711-21. PMID: 16040814
Fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea] is an atypical anxiolytic agent with unknown molecular target that has previously been demonstrated both in rodents and human to exert anxiolytic activity. Here, we report that fenobam...
5.
Constitutive activity modulation of human metabotropic glutamate 5a receptors in HEK293 cells: a role for key amino-terminal cysteine residues
Muhlemann A, Diener C, Fischer C, Piussi J, Stucki A, Porter R
Br J Pharmacol . 2005 Feb; 144(8):1118-25. PMID: 15700023
1. Several combinations of cysteine to serine mutations at positions 57, 93, 99 and 129 in the extracellular N-terminal domain of human metabotropic 5a (hmGlu5a) receptors were produced and expressed...