Pari Malherbe
Overview
Explore the profile of Pari Malherbe including associated specialties, affiliations and a list of published articles.
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27
Citations
637
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Recent Articles
1.
Zemoura K, Ralvenius W, Malherbe P, Benke D
Neuropharmacology
. 2016 Apr;
108:172-8.
PMID: 27108932
Neuropathic pain is associated with impaired inhibitory control of spinal dorsal horn neurons, which are involved in processing pain signals. The metabotropic GABAB receptor is an important component of the...
2.
Maccioni P, Vargiolu D, Thomas A, Malherbe P, Mugnaini C, Corelli F, et al.
Psychopharmacology (Berl)
. 2014 Nov;
232(10):1831-41.
PMID: 25420609
Rationale: Treatment with positive allosteric modulators (PAMs) of the GABAB receptor (GABAB PAMs) inhibits several alcohol-motivated behaviors in rodents, including operant, oral alcohol self-administration. Objectives: The present study assessed the...
3.
Malherbe P, Knoflach F, Marcuz A, Bohnert C, Weber M, Knust H, et al.
Neuropharmacology
. 2014 Aug;
86:259-72.
PMID: 25107588
The NK3 receptor is a GPCR that is prominently expressed in limbic areas of the brain, many of which have been implicated in schizophrenia. Phase II clinical trials in schizophrenia...
4.
Frau R, Bini V, Pillolla G, Malherbe P, Pardu A, Thomas A, et al.
CNS Neurosci Ther
. 2014 Apr;
20(7):679-84.
PMID: 24703381
Background: Converging evidence points to the involvement of γ-amino-butyric acid B receptors (GABABRs) in the regulation of information processing. We previously showed that GABABR agonists exhibit antipsychotic-like properties in rodent...
5.
Loi B, Maccioni P, Lobina C, Carai M, Gessa G, Thomas A, et al.
Alcohol
. 2012 Dec;
47(1):69-73.
PMID: 23218664
Previous research has demonstrated that treatment with the positive allosteric modulator (PAM) of the GABA(B) receptor (GABA(B) PAM), rac-BHFF, suppressed lever-responding for alcohol and amount of self-administered alcohol in Sardinian...
6.
Morairty S, Revel F, Malherbe P, Moreau J, Valladao D, Wettstein J, et al.
PLoS One
. 2012 Jul;
7(7):e39131.
PMID: 22768296
The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential hypnotic medications. It is currently...
7.
Bissantz C, Bohnert C, Hoffmann T, Marcuz A, Schnider P, Malherbe P
J Med Chem
. 2012 May;
55(11):5061-76.
PMID: 22574973
The neurokinins are neuropeptides that elicit their effect through three GPCRs called NK(1), NK(2), and NK(3). Compounds 5 and 6 are dual hNK(1) (K(i) of 0.7 and 0.3 nM) and...
8.
Kratochwil N, Gatti-McArthur S, Hoener M, Lindemann L, Christ A, Green L, et al.
Curr Top Med Chem
. 2011 Apr;
11(15):1902-24.
PMID: 21470172
G protein-coupled receptors (GPCRs) share a common architecture consisting of seven transmembrane (TM) domains. Various lines of evidence suggest that this fold provides a generic binding pocket within the TM...
9.
Malherbe P, Ballard T, Ratni H
Expert Opin Ther Pat
. 2011 Mar;
21(5):637-55.
PMID: 21417773
Introduction: The neurokinin 3 (NK(3)) receptor is a GPCR that has been shown to modulate monoaminergic systems within regions of the brain implicated in schizophrenia. Preclinical and Phase II clinical...
10.
Malherbe P, Roche O, Marcuz A, Kratzeisen C, Wettstein J, Bissantz C
Mol Pharmacol
. 2010 Apr;
78(1):81-93.
PMID: 20404073
The orexins and their receptors are involved in the regulation of arousal and sleep-wake cycle. Clinical investigation with almorexant has indicated that this dual OX antagonist is efficacious in inducing...