Andreas Marx
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Explore the profile of Andreas Marx including associated specialties, affiliations and a list of published articles.
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262
Citations
2702
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Recent Articles
11.
Kasprzyk R, Rieth S, Heid P, Stengel F, Marx A
Angew Chem Int Ed Engl
. 2024 Sep;
63(51):e202411203.
PMID: 39233478
Posttranslational modifications (PTMs) greatly enhance the functional diversity of proteins, surpassing the number of gene-encoded variations. One intriguing PTM is ADP-ribosylation, which utilizes nicotinamide adenine dinucleotide (NAD) as a substrate...
12.
Stumpf F, Muller S, Marx A
RSC Chem Biol
. 2024 Aug;
5(9):833-840.
PMID: 39211475
Rlig1 is the first RNA ligase identified in humans utilising a classical 5'-3' ligation mechanism. It is a conserved enzyme in all vertebrates and is mutated in various cancers. During...
13.
Arnold J, Ghosh S, Kasprzyk R, Brakonier M, Hanna M, Marx A, et al.
Nucleic Acids Res
. 2024 Aug;
52(17):10533-10542.
PMID: 39162230
RNA 2'-phosphotransferase Tpt1 catalyzes the removal of an internal RNA 2'-PO4 via a two-step mechanism in which: (i) the 2'-PO4 attacks NAD+ C1″ to form an RNA-2'-phospho-(ADP-ribose) intermediate and nicotinamide;...
14.
Kienle S, Schneider T, Bernecker C, Bracker J, Marx A, Kovermann M, et al.
Chembiochem
. 2024 Jul;
25(22):e202400478.
PMID: 39022855
Similar to ubiquitin, the ubiquitin-like protein NEDD8 is not only conjugated to other proteins but is itself subject to posttranslational modifications including lysine acetylation. Yet, compared to ubiquitin, only little...
15.
Steinfeldt T, Marx A, Dauster M
Anasthesiol Intensivmed Notfallmed Schmerzther
. 2024 Mar;
59(3):138-158.
PMID: 38513640
By implementation of sonography regional anesthesia became more relevant in the daily practice of anesthesia and pain therapy. Due to visualized needle guidance ultrasound supports more safety during needle placement....
16.
Rieth S, Spliesgar D, Orth J, Lehner M, Kasprzyk R, Stengel F, et al.
Chembiochem
. 2024 Jan;
25(5):e202300797.
PMID: 38236015
ADP-ribosylation is a post-translational modification catalyzed by the enzyme family of polyadenosine diphosphate (ADP)-ribose) polymerases (PARPs). This enzymatic process involves the transfer of single or multiple ADP-ribose molecules onto proteins,...
17.
Nippa D, Atz K, Hohler R, Muller A, Marx A, Bartelmus C, et al.
Nat Chem
. 2023 Nov;
16(2):239-248.
PMID: 37996732
Late-stage functionalization is an economical approach to optimize the properties of drug candidates. However, the chemical complexity of drug molecules often makes late-stage diversification challenging. To address this problem, a...
18.
Saumer P, Scheffner M, Marx A, Stengel F
Nucleic Acids Res
. 2023 Nov;
52(1):101-113.
PMID: 37994785
Post-translational modifications (PTMs) of histones have fundamental effects on chromatin structure and function. While the impact of PTMs on the function of core histones are increasingly well understood, this is...
19.
Helm M, Bohnsack M, Carell T, Dalpke A, Entian K, Ehrenhofer-Murray A, et al.
ACS Chem Biol
. 2023 Nov;
18(12):2441-2449.
PMID: 37962075
The chemical biology of native nucleic acid modifications has seen an intense upswing, first concerning DNA modifications in the field of epigenetics and then concerning RNA modifications in a field...
20.
Akyuz O, Missun M, Rosenberg R, Scheffner M, Marx A, Colfen H
Nanoscale Adv
. 2023 Nov;
5(22):6061-6068.
PMID: 37941944
Protein-stabilized gold nanoclusters (AuNCs) are fascinating nanostructures with exciting properties owing to their ultra-small sizes and functional shell. However, their applications under extreme conditions are still complicated, waiting for programmable...