Andreas Brunschweiger
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Explore the profile of Andreas Brunschweiger including associated specialties, affiliations and a list of published articles.
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40
Citations
524
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Recent Articles
1.
Schlosser V, Lightfoot H, Leemann C, Bejoy A, Tiwari S, Schlosshauer J, et al.
Noncoding RNA
. 2025 Jan;
11(1.
PMID: 39846686
Background: Despite tremendous advances in antiretroviral therapy (ART) against HIV-1 infections, no cure or vaccination is available. Therefore, discovering novel therapeutic strategies remains an urgent need. In that sense, miRNAs...
2.
Roth C, Paulini L, Hoffmann M, Mosler T, Dikic I, Brunschweiger A, et al.
Biofactors
. 2024 Apr;
50(6):1113-1133.
PMID: 38655699
The multidomain protein BAG3 exerts pleiotropic oncogenic functions in many tumor entities including glioblastoma (GBM). Here, we compared BAG3 protein-protein interactions in either adherently cultured or stem-like cultured U251 GBM...
3.
Willems S, Detta E, Baldini L, Tietz D, Trabocchi A, Brunschweiger A
ACS Omega
. 2024 Feb;
9(7):7719-7724.
PMID: 38405463
In DNA-encoded library synthesis, amine-substituted building blocks are prevalent. We explored isocyanide multicomponent reactions to diversify DNA-tagged amines and reported the Ugi-azide reaction with high yields and a good substrate...
4.
Dinter R, Willems S, Nissalk T, Hasturk O, Brunschweiger A, Kockmann N
Front Chem
. 2023 Aug;
11:1244043.
PMID: 37608867
The transfer from batch to flow chemistry is often based on commercial microfluidic equipment, such as costly complete reactor systems, which cannot be easily tailored to specific requirements of technologies...
5.
Chines S, Ehrt C, Potowski M, Biesenkamp F, Grutzbach L, Brunner S, et al.
Chem Sci
. 2022 Nov;
13(37):11221-11231.
PMID: 36320474
Databases contain millions of reactions for compound synthesis, rendering selection of reactions for forward synthetic design of small molecule screening libraries, such as DNA-encoded libraries (DELs), a big data challenge....
6.
Skopic M, Dos Santos Smith D, Gohla A, Kunig V, Brunschweiger A
Methods Mol Biol
. 2022 Sep;
2541:89-104.
PMID: 36083549
Libraries of DNA-encoded compounds (DELs) are a validated screening technology for drug discovery. Here we describe a library synthesis strategy that starts with a solid phase-bound, chemically very stable hexathymidine...
7.
Gotte K, Dinter R, Justen L, Kockmann N, Brunschweiger A
ACS Omega
. 2022 Aug;
7(32):28369-28377.
PMID: 35990424
DNA-encoded library technologies require high-throughput, compatible, and well automatable platforms for chemistry development, building block rehearsal, and library synthesis. An affinity-based process using Watson-Crick interactions was developed that enables purification...
8.
Potowski M, Kunig V, Eberlein L, Skopic M, Vakalopoulos A, Kast S, et al.
Front Chem
. 2022 Jun;
10:894563.
PMID: 35755251
DNA-encoded libraries are a prime technology for target-based small molecule screening. Native DNA used as genetic compound barcode is chemically vulnerable under many reaction conditions. DNA barcodes that are composed...
9.
Skopic M, Losch F, McMillan A, Willeke N, Malenica M, Bering L, et al.
Org Lett
. 2022 Feb;
24(6):1383-1387.
PMID: 35113572
Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide-aldehyde conjugates could be condensed with SnAP reagents and...
10.