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Andrea Weiler

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Articles 9
Citations 152
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Recent Articles
1.
Ellis-Connell A, Balgeman A, Zarbock K, Barry G, Weiler A, Egan J, et al.
J Virol . 2017 Nov; 92(3). PMID: 29118125
Developing biological interventions to control human immunodeficiency virus (HIV) replication in the absence of antiretroviral therapy (ART) could contribute to the development of a functional cure. As a potential alternative...
2.
Bailey A, Lauck M, Mohns M, Peterson E, Beheler K, Brunner K, et al.
Sci Transl Med . 2015 Sep; 7(305):305ra144. PMID: 26378244
Human pegivirus (HPgV)-formerly known as GB virus C and hepatitis G virus-is a poorly characterized RNA virus that infects about one-sixth of the global human population and is transmitted frequently...
3.
Bailey A, Lauck M, Weiler A, Sibley S, Dinis J, Bergman Z, et al.
PLoS One . 2014 Mar; 9(3):e90714. PMID: 24651479
Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their...
4.
Weiler A, May G, Qi Y, Wilson N, Watkins D
Immunogenetics . 2006 Nov; 58(12):1003-9. PMID: 17106666
Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous...
5.
OLeary V, Mills J, Parle-McDermott A, Pangilinan F, Molloy A, Cox C, et al.
Am J Med Genet A . 2005 Sep; 138A(2):99-106. PMID: 16145688
The enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR) plays a key role in cellular folate metabolism. The A222V (677C->T) polymorphism is a confirmed neural tube defect (NTD) risk factor within Irish and other...
6.
OLeary V, Mills J, Pangilinan F, Kirke P, Cox C, Conley M, et al.
Mol Genet Metab . 2005 Jun; 85(3):220-7. PMID: 15979034
Methionine synthase reductase (MTRR) regenerates methylated cobalamin levels from the oxidised cob(II)alamin form and in so doing plays a crucial role in maintaining the active state of methionine synthase (MTR)....
7.
Swanson D, Pangilinan F, Mills J, Kirke P, Conley M, Weiler A, et al.
Birth Defects Res A Clin Mol Teratol . 2005 Mar; 73(4):239-44. PMID: 15782407
Background: Decreased maternal folate levels are associated with having a child with a neural tube defect (NTD), and periconceptual folic acid supplementation reduces this risk by >50%. Vitamin B(12) (as...
8.
Parle-McDermott A, McManus E, Mills J, OLeary V, Pangilinan F, Cox C, et al.
Mol Genet Metab . 2003 Dec; 80(4):463-8. PMID: 14654360
Methionine synthase and methylmalonyl-CoA mutase (mutase) are the only two known vitamin B(12) (B(12)) dependent enzymes in humans. A lower level of B(12) has been shown to be an independent...
9.
OLeary V, Mills J, Kirke P, Parle-McDermott A, Swanson D, Weiler A, et al.
Mol Genet Metab . 2003 Jun; 79(2):129-33. PMID: 12809644
The folate receptor beta (FRbeta) gene encodes a receptor that binds and transports 5-methyltetrahydrofolate. FRbeta polymorphisms may potentially alter folate delivery and are likely candidates for an association with neural...