Polymorphisms in Eight Host Genes Associated with Control of HIV Replication Do Not Mediate Elite Control of Viral Replication in SIV-infected Indian Rhesus Macaques

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2006 Nov 16

PMID 17106666

Citations 11

Authors

Andrea Weiler

Gemma E May

Ying Qi

Nancy Wilson

David I Watkins

Affiliations

Soon will be listed here.

Abstract

Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-alpha, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.

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