Andrea Strasser
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Explore the profile of Andrea Strasser including associated specialties, affiliations and a list of published articles.
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51
Citations
523
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Recent Articles
1.
Tropmann K, Seibel-Ehlert U, Littmann T, Strasser A
Bioorg Med Chem Lett
. 2021 Oct;
52:128388.
PMID: 34600035
So far, only little is known about the internalization process of the histamine H receptor (HR). One promising approach to study such dynamic processes is the use of agonistic fluorescent...
2.
Horing C, Conrad M, Soldner C, Wang J, Sticht H, Strasser A, et al.
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576210
G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits...
3.
Seibel-Ehlert U, Plank N, Inoue A, Bernhardt G, Strasser A
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34575903
G protein activation represents an early key event in the complex GPCR signal transduction process and is usually studied by label-dependent methods targeting specific molecular events. However, the constrained environment...
4.
Tropmann K, Bresinsky M, Forster L, Monnich D, Buschauer A, Wittmann H, et al.
J Med Chem
. 2021 Jun;
64(12):8684-8709.
PMID: 34110814
3-(2-Amino-4-methylthiazol-5-yl)propyl-substituted carbamoylguanidines are potent, subtype-selective histamine H receptor (HR) agonists, but their applicability as pharmacological tools to elucidate the largely unknown HR functions in the central nervous system (CNS) is...
5.
Horing C, Seibel U, Tropmann K, Gratz L, Monnich D, Pitzl S, et al.
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33182741
In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of...
6.
Kirchhof S, Strasser A, Wittmann H, Messmann V, Hammer N, Goepferich A, et al.
J Mater Chem B
. 2020 Apr;
3(3):449-457.
PMID: 32262047
Eight-armed poly(ethylene glycol) was functionalized with furyl and maleimide groups. The two macromonomers were cross-linked by Diels-Alder (DA) reactions and the degradation behavior of the formed hydrogels was investigated. UV...
7.
Dolles D, Hoffmann M, Gunesch S, Marinelli O, Moller J, Santoni G, et al.
J Med Chem
. 2018 Feb;
61(4):1646-1663.
PMID: 29400965
The enzyme butyrylcholinesterase (BChE) and the human cannabinoid receptor 2 (hCBR) represent promising targets for pharmacotherapy in the later stages of Alzheimer's disease. We merged pharmacophores for both targets into...
8.
Strasser A, Wittmann H, Seifert R
Trends Pharmacol Sci
. 2017 Jun;
38(8):717-732.
PMID: 28645833
Previously, drugs were developed focusing on target affinity and selectivity. However, it is becoming evident that the drug-target residence time, related to the off-rate, is an important parameter for successful...
9.
Wittmann H, Strasser A
Naunyn Schmiedebergs Arch Pharmacol
. 2017 Feb;
390(6):595-612.
PMID: 28220211
Within the last years, for several ligands, binding to G protein-coupled receptors or other target proteins, a binding of the ligand in two different orientations is described. One appropriate experimental...
10.
Strasser A, Wittmann H
Handb Exp Pharmacol
. 2017 Jan;
241:31-61.
PMID: 28110354
Several experimental techniques to analyse histamine receptors are available, e.g. pharmacological characterisation of known or new compounds by different types of assays or mutagenesis studies. To obtain insights into the...