Andrea Sacchetti
Overview
Explore the profile of Andrea Sacchetti including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
1249
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Recent Articles
1.
Fobian S, Amin M, Sacchetti A, Seynhaeve A, Oei A, Ten Hagen T
J Control Release
. 2025 Feb;
380:1202.
PMID: 39920015
No abstract available.
2.
Scholtes M, Akbarzadeh M, Galaras A, Nakauma-Gonzales J, Bazrafshan A, Solanki V, et al.
Cancer Lett
. 2025 Feb;
614:217506.
PMID: 39892702
Somatic mutations in ARID1A (AT-rich interactive domain-containing protein 1A) are present in approximately 25 % of bladder cancers (BC) and are associated with poor prognosis. With a view to discover...
3.
Fobian S, Amin M, Sacchetti A, Oei A, Ten Hagen T
J Control Release
. 2025 Jan;
379:236-250.
PMID: 39798703
The recent approval of pembrolizumab in recurrent or metastatic cervical cancer warrants further investigations into the usefulness of immunotherapies for more durable and less radical interventions. In this study, the...
4.
Trerotola M, Relli V, Tripaldi R, Simeone P, Guerra E, Sacchetti A, et al.
Mol Biol Cell
. 2025 Jan;
36(3):ar38.
PMID: 39785844
The transmembrane glycoproteins Trop-1/EpCAM and Trop-2 independently trigger Ca and kinase signals for cell growth and tumor progression. Our findings indicated that Trop-1 and Trop-2 tightly colocalize at macroscopic, ruffle-like...
5.
Windster J, Windster J, Kakiailatu N, Kakiailatu N, Kuil L, Kuil L, et al.
Gastroenterology
. 2024 Dec;
PMID: 39725172
Background & Aims: The enteric nervous system (ENS), which is composed of neurons and glia, regulates intestinal motility. Hirschsprung disease (HSCR) results from defects in ENS formation; however, although neuronal...
6.
Verhagen M, Xu T, Stabile R, Joosten R, Tucci F, van Royen M, et al.
iScience
. 2024 Sep;
27(9):110658.
PMID: 39246444
Intra-tumor heterogeneity, i.e., the presence of diverse cell types and subpopulations within tumors, presents a significant obstacle in cancer treatment due to its negative consequences for resistance to therapy and...
7.
Verhagen M, Joosten R, Schmitt M, Valimaki N, Sacchetti A, Rajamaki K, et al.
Nat Genet
. 2024 Jun;
56(7):1456-1467.
PMID: 38902475
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown to suppress intestinal stemness. Here, we used Paneth...
8.
Xu T, Verhagen M, Teeuwssen M, Sun W, Joosten R, Sacchetti A, et al.
Cell Death Differ
. 2024 Feb;
31(3):360-377.
PMID: 38365970
Phenotypic plasticity, defined as the ability of individual cells with stable genotypes to exert different phenotypes upon exposure to specific environmental cues, represent the quintessential hallmark of the cancer cell...
9.
Verhagen M, Joosten R, Schmitt M, Valimaki N, Sacchetti A, Rajamaki K, et al.
bioRxiv
. 2023 Oct;
PMID: 37873142
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, was shown to suppress intestinal stemness. Here, we employed Paneth cells...
10.
Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Ceci M, et al.
Mol Cancer Ther
. 2023 Mar;
22(6):790-804.
PMID: 36921314
Next-generation Trop-2-targeted therapy against advanced cancers is hampered by expression of Trop-2 in normal tissues. We discovered that Trop-2 undergoes proteolytic activation by ADAM10 in cancer cells, leading to the...