Andrea S Rothmeier
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Explore the profile of Andrea S Rothmeier including associated specialties, affiliations and a list of published articles.
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10
Citations
345
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Recent Articles
1.
Sluka S, Stampfli S, Akhmedov A, Klein-Rodewald T, Sanz-Moreno A, Horsch M, et al.
Haematologica
. 2020 Oct;
105(10):2484-2495.
PMID: 33054088
Tissue factor is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186-Cys209 of human tissue factor shows high evolutionary conservation and in vitro evidence suggests that it significantly...
2.
Rothmeier A, Versteeg H, Ruf W
J Thromb Haemost
. 2019 Feb;
17(4):627-634.
PMID: 30740873
Essentials Prothrombotic extracellular vesicles (EV) carry agonist pathway-specific proteomes Agonists for protease activated receptor (PAR) 2 signaling have distinct effects on EV composition PAR2 signaling rapidly generates prothrombotic EV and...
3.
Rothmeier A, Liu E, Chakrabarty S, Disse J, Mueller B, Ostergaard H, et al.
Blood
. 2017 Dec;
131(6):674-685.
PMID: 29246902
The tissue factor (TF) pathway serves both hemostasis and cell signaling, but how cells control these divergent functions of TF remains incompletely understood. TF is the receptor and scaffold of...
4.
Kamikubo Y, Mendolicchio G, Zampolli A, Marchese P, Rothmeier A, Orje J, et al.
Blood
. 2017 Jul;
130(14):1661-1670.
PMID: 28729433
Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation...
5.
Rothmeier A, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, et al.
Arterioscler Thromb Vasc Biol
. 2017 May;
37(7):1323-1331.
PMID: 28495929
Objective: Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange. How these mechanisms contribute to keeping TF in a...
6.
Ruf W, Rothmeier A, Graf C
Thromb Res
. 2016 Apr;
140 Suppl 1:S1-7.
PMID: 27067961
Cancer-associated thrombosis remains a significant complication in the clinical management of cancer and interactions of the hemostatic system with cancer biology continue to be elucidated. Here, we review recent progress...
7.
Rothmeier A, Marchese P, Petrich B, Furlan-Freguia C, Ginsberg M, Ruggeri Z, et al.
J Clin Invest
. 2015 Feb;
125(4):1471-84.
PMID: 25705884
Extracellular ATP is a signal of tissue damage and induces macrophage responses that amplify inflammation and coagulation. Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin...
8.
Rothmeier A, Ruf W
Semin Immunopathol
. 2011 Oct;
34(1):133-49.
PMID: 21971685
Protease-activated receptors (PARs) are G protein-coupled receptors that are activated by proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular proteases. While coagulation proteases activate PARs to...
9.
Rothmeier A, Schneiders U, Wiedmann R, Ischenko I, Bruns C, Rudy A, et al.
Int J Cancer
. 2010 Feb;
127(5):1096-105.
PMID: 20143389
Treatment of pancreatic cancer remains a major challenge and new anticancer drugs are urgently required. Our study presents the marine natural compound spongistatin 1 as a promising experimental drug. Spongistatin...
10.
Rothmeier A, Ischenko I, Joore J, Garczarczyk D, Furst R, Bruns C, et al.
FASEB J
. 2008 Dec;
23(4):1127-37.
PMID: 19056838
The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and...