Andrea Reboldi
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Explore the profile of Andrea Reboldi including associated specialties, affiliations and a list of published articles.
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35
Citations
2085
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Recent Articles
1.
Kellogg T, Ceglia S, Mortzfeld B, Tanna T, Zeamer A, Mancini M, et al.
J Exp Med
. 2024 Nov;
222(1).
PMID: 39589553
The role of microbes and their metabolites in modulating tuft cell (TC) dynamics in the large intestine and the relevance of this pathway to infections is unknown. Here, we uncover...
2.
Dang E, Reboldi A
Trends Immunol
. 2024 Oct;
45(11):861-870.
PMID: 39424470
Cholesterol metabolites, particularly oxidized forms known as oxysterols, play crucial roles in modulating immune and metabolic processes across various tissues. Concentrations of local cholesterol and its metabolites influence tissue-specific immune...
3.
Bettini E, Chudnovskiy A, Protti G, Nakadakari-Higa S, Ceglia S, Castano D, et al.
bioRxiv
. 2024 May;
PMID: 38798523
Nucleoside-modified mRNA vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cells. The lipid nanoparticle (LNP) component of mRNA vaccines possesses inherent adjuvant activity. However, to...
4.
Canales-Herrerias P, Uzzan M, Seki A, Czepielewski R, Verstockt B, Livanos A, et al.
Sci Immunol
. 2024 Apr;
9(94):eadg7549.
PMID: 38640252
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of...
5.
Kellogg T, Ceglia S, Mortzfeld B, Zeamer A, Foley S, Ward D, et al.
bioRxiv
. 2024 Feb;
PMID: 38352546
Metabolic byproducts of the intestinal microbiota are crucial in maintaining host immune tone and shaping inter-species ecological dynamics. Among these metabolites, succinate is a driver of tuft cell (TC) differentiation...
6.
Raso F, Liu S, Simpson M, Barton G, Mayer C, Acharya M, et al.
Immunity
. 2023 Sep;
56(10):2373-2387.e8.
PMID: 37714151
Immunoglobulin A (IgA) maintains commensal communities in the intestine while preventing dysbiosis. IgA generated against intestinal microbes assures the simultaneous binding to multiple, diverse commensal-derived antigens. However, the exact mechanisms...
7.
Howley K, Berthelette A, Ceglia S, Kang J, Reboldi A
bioRxiv
. 2023 Mar;
PMID: 36993524
Lymphoid tissue inducer (LTi) cells develop during intrauterine life and rely on developmental programs to initiate the organogenesis of secondary lymphoid organs (SLOs). This evolutionary conserved process endows the fetus...
8.
Frascoli M, Ferraj E, Miu B, Malin J, Spidale N, Cowan J, et al.
Immunity
. 2023 Feb;
56(3):562-575.e6.
PMID: 36842431
Dietary components and metabolites have a profound impact on immunity and inflammation. Here, we investigated how sensing of cholesterol metabolite oxysterols by γδ T cells impacts their tissue residency and...
9.
Canales-Herrerias P, Uzzan M, Seki A, Czepielewski R, Verstockt B, Livanos A, et al.
bioRxiv
. 2023 Jan;
PMID: 36711839
Targeting the α4β7-MAdCAM-1 axis with vedolizumab (VDZ) is a front-line therapeutic paradigm in ulcerative colitis (UC). However, mechanism(s) of action (MOA) of VDZ remain relatively undefined. Here, we examined three...
10.
Ceglia S, Berthelette A, Howley K, Li Y, Mortzfeld B, Bhattarai S, et al.
Nat Immunol
. 2023 Jan;
24(3):531-544.
PMID: 36658240
Immunoglobulin A (IgA) secretion by plasma cells, terminally differentiated B cells residing in the intestinal lamina propria, assures microbiome homeostasis and protects the host against enteric infections. Exposure to diet-derived...