Andrea Rasola
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Explore the profile of Andrea Rasola including associated specialties, affiliations and a list of published articles.
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73
Citations
2878
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Recent Articles
11.
Cannino G, Urbani A, Gaspari M, Varano M, Negro A, Filippi A, et al.
Cell Death Differ
. 2022 May;
29(12):2335-2346.
PMID: 35614131
Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined. Here we show that...
12.
Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi F, Scantamburlo F, et al.
Cell Death Differ
. 2022 Apr;
29(10):1996-2008.
PMID: 35393510
Neurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in...
13.
Triveri A, Sanchez-Martin C, Torielli L, Serapian S, Marchetti F, DAcerno G, et al.
J Mol Biol
. 2022 Feb;
434(17):167468.
PMID: 35101454
Herein we examine the determinants of the allosteric inhibition of the mitochondrial chaperone TRAP1 by a small molecule ligand. The knowledge generated is harnessed into the design of novel derivatives...
14.
Triveri A, Serapian S, Marchetti F, Doria F, Pavoni S, Cinquini F, et al.
J Chem Inf Model
. 2021 Sep;
61(9):4687-4700.
PMID: 34468141
The SARS-CoV-2 spike (S) protein is exposed on the viral surface and is the first point of contact between the virus and the host. For these reasons it represents the...
15.
Ciscato F, Chiara F, Filadi R, Rasola A
Bio Protoc
. 2021 Aug;
11(14):e4087.
PMID: 34395726
The crucial role of hexokinase 2 (HK2) in the metabolic rewiring of tumors is now well established, which makes it a suitable target for the design of novel therapies. However,...
16.
Carrer A, Tommasin L, Sileikyte J, Ciscato F, Filadi R, Urbani A, et al.
Nat Commun
. 2021 Aug;
12(1):4835.
PMID: 34376679
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but the mechanism(s) leading to channel formation remain undefined. Here, to shed light on the structural requirements...
17.
Masgras I, Laquatra C, Cannino G, Serapian S, Colombo G, Rasola A
Semin Cancer Biol
. 2021 Jul;
76:45-53.
PMID: 34242740
TRAP1, the mitochondrial component of the Hsp90 family of molecular chaperones, displays important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape metabolism, dynamically tuning it with the...
18.
Errico A, Stocco A, Riccardi V, Gambalunga A, Bassetto F, Grigatti M, et al.
Cancers (Basel)
. 2021 Jun;
13(10).
PMID: 34066061
Plexiform neurofibromas (Pnfs) are benign peripheral nerve sheath tumors that are major features of the human genetic syndrome, neurofibromatosis type 1 (NF1). Pnfs are derived from Schwann cells (SCs) undergoing...
19.
Serapian S, Sanchez-Martin C, Moroni E, Rasola A, Colombo G
Trends Pharmacol Sci
. 2021 May;
42(7):566-576.
PMID: 33992469
TRAP1, the mitochondrial isoform of heat shock protein (Hsp)90 chaperones, is a key regulator of metabolism and organelle homeostasis in diverse pathological states. While selective TRAP1 targeting is an attractive...
20.
Ciscato F, Ferrone L, Masgras I, Laquatra C, Rasola A
Int J Mol Sci
. 2021 May;
22(9).
PMID: 33946854
Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family, mainly expressed in insulin-sensitive tissues....