Francesco Ciscato
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Explore the profile of Francesco Ciscato including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
362
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Recent Articles
1.
Coluccino G, Negro A, Filippi A, Bean C, Muraca V, Gissi C, et al.
Commun Biol
. 2024 Nov;
7(1):1486.
PMID: 39528709
Cyclophilin (CyP) D is a regulator of the mitochondrial F-ATP synthase. Here we report the discovery of a form of CyPD lacking the first 10 (mouse) or 13 (human) N-terminal...
2.
Scantamburlo F, Masgras I, Ciscato F, Laquatra C, Frigerio F, Cinquini F, et al.
J Chem Inf Model
. 2024 Oct;
64(21):8274-8282.
PMID: 39440601
The disruptive impact of the COVID-19 pandemic has led the scientific community to undertake an unprecedented effort to characterize viral infection mechanisms. Among these, interactions between the viral glycosylated Spike...
3.
Ciscato F, Masgras I, Gori A, Fantuz M, Bergamaschi G, Komarov D, et al.
Cells
. 2024 Jul;
13(13.
PMID: 38995012
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas that can arise both sporadically and in patients with the genetic syndrome Neurofibromatosis type 1 (NF1). Prognosis is dismal, as large...
4.
Damanti C, Ferrone L, Gaffo E, Garbin A, Tosato A, Contarini G, et al.
Cancer Commun (Lond)
. 2023 Apr;
43(5):630-634.
PMID: 37014813
No abstract available.
5.
Cannino G, Urbani A, Gaspari M, Varano M, Negro A, Filippi A, et al.
Cell Death Differ
. 2022 May;
29(12):2335-2346.
PMID: 35614131
Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined. Here we show that...
6.
Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi F, Scantamburlo F, et al.
Cell Death Differ
. 2022 Apr;
29(10):1996-2008.
PMID: 35393510
Neurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in...
7.
Ciscato F, Chiara F, Filadi R, Rasola A
Bio Protoc
. 2021 Aug;
11(14):e4087.
PMID: 34395726
The crucial role of hexokinase 2 (HK2) in the metabolic rewiring of tumors is now well established, which makes it a suitable target for the design of novel therapies. However,...
8.
Carrer A, Tommasin L, Sileikyte J, Ciscato F, Filadi R, Urbani A, et al.
Nat Commun
. 2021 Aug;
12(1):4835.
PMID: 34376679
F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but the mechanism(s) leading to channel formation remain undefined. Here, to shed light on the structural requirements...
9.
Ciscato F, Ferrone L, Masgras I, Laquatra C, Rasola A
Int J Mol Sci
. 2021 May;
22(9).
PMID: 33946854
Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family, mainly expressed in insulin-sensitive tissues....
10.
Ciscato F, Filadi R, Masgras I, Pizzi M, Marin O, Damiano N, et al.
EMBO Rep
. 2020 May;
21(7):e49117.
PMID: 32383545
Cancer cells undergo changes in metabolic and survival pathways that increase their malignancy. Isoform 2 of the glycolytic enzyme hexokinase (HK2) enhances both glucose metabolism and resistance to death stimuli...