Andrea Oeckinghaus
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Explore the profile of Andrea Oeckinghaus including associated specialties, affiliations and a list of published articles.
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23
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2950
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Recent Articles
1.
Schleinhege R, Neumann I, Oeckinghaus A, Schwab A, Petho Z
Matrix Biol
. 2024 Dec;
135():70-86.
PMID: 39662708
Rationale: Pancreatic stellate cells (PSCs) produce a collagen-rich connective tissue in chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Ca-permeable ion channels such as ORAI1 are known to affect PSC proliferation...
2.
Rasche R, Apken L, Michalke E, Kummel D, Oeckinghaus A
FEBS Lett
. 2024 Apr;
598(14):1769-1782.
PMID: 38604989
κB-Ras (NF-κB inhibitor-interacting Ras-like protein) GTPases are small Ras-like GTPases but harbor interesting differences in important sequence motifs. They act in a tumor-suppressive manner as negative regulators of Ral (Ras-like)...
3.
Postler T, Wang A, Brundu F, Wang P, Wu Z, Butler K, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(46):e2312595120.
PMID: 37931099
The NF-κB family of transcription factors and the Ras family of small GTPases are important mediators of proproliferative signaling that drives tumorigenesis and carcinogenesis. The κB-Ras proteins were previously shown...
4.
Petho Z, Najder K, Beel S, Fels B, Neumann I, Schimmelpfennig S, et al.
JCI Insight
. 2023 Aug;
8(19).
PMID: 37643024
Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression...
5.
Kolloch L, Kreinest T, Meisterernst M, Oeckinghaus A
Int J Mol Sci
. 2022 Jan;
23(2).
PMID: 35054996
Inhibition of the dual function cell cycle and transcription kinase CDK7 is known to affect the viability of cancer cells, but the mechanisms underlying cell line-specific growth control remain poorly...
6.
Stefanello S, Luchtefeld I, Liashkovich I, Petho Z, Azzam I, Bulk E, et al.
Adv Sci (Weinh)
. 2021 Oct;
8(22):e2102757.
PMID: 34658143
Nuclear pore complexes (NPCs) selectively mediate all nucleocytoplasmic transport and engage in fundamental cell-physiological processes. It is hypothesized that NPCs are critical for malignant transformation and survival of lung cancer...
7.
Apken L, Oeckinghaus A
Int Rev Cell Mol Biol
. 2021 Jun;
361:21-105.
PMID: 34074494
The RAL proteins RALA and RALB belong to the superfamily of small RAS-like GTPases (guanosine triphosphatases). RAL GTPases function as molecular switches in cells by cycling through GDP- and GTP-bound...
8.
Fitzian K, Bruckner A, Brohee L, Zech R, Antoni C, Kiontke S, et al.
Mol Cell
. 2021 May;
81(13):2705-2721.e8.
PMID: 33974911
The TSC complex is a critical negative regulator of the small GTPase Rheb and mTORC1 in cellular stress signaling. The TSC2 subunit contains a catalytic GTPase activating protein domain and...
9.
Beel S, Kolloch L, Apken L, Jurgens L, Bolle A, Sudhof N, et al.
Nat Commun
. 2020 Jul;
11(1):3409.
PMID: 32641778
Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher...
10.
Escobar-Hoyos L, Penson A, Kannan R, Cho H, Pan C, Singh R, et al.
Cancer Cell
. 2020 Jun;
38(2):198-211.e8.
PMID: 32559497
Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations collaborate to promote this cancer is unknown. Here, we uncover sequence-specific changes in...