Andrea M Griesinger
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Explore the profile of Andrea M Griesinger including associated specialties, affiliations and a list of published articles.
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28
Citations
888
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Recent Articles
11.
Fu R, Norris G, Willard N, Griesinger A, Riemondy K, Amani V, et al.
Neuro Oncol
. 2022 Oct;
25(4):786-798.
PMID: 36215273
Background: The diverse cellular constituents of childhood brain tumor ependymoma, recently revealed by single cell RNA-sequencing, may underly therapeutic resistance. Here we use spatial transcriptomics to further advance our understanding...
12.
Panwalkar P, Tamrazi B, Dang D, Chung C, Sweha S, Natarajan S, et al.
Sci Transl Med
. 2021 Oct;
13(614):eabc0497.
PMID: 34613815
Childhood posterior fossa group A ependymomas (PFAs) have limited treatment options and bear dismal prognoses compared to group B ependymomas (PFBs). PFAs overexpress the oncohistone-like protein EZHIP (enhancer of Zeste...
13.
Riemondy K, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger A, et al.
Neuro Oncol
. 2021 Jun;
24(2):273-286.
PMID: 34077540
Background: Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease progression. We aimed to determine the influence of neoplastic and immune cell...
14.
Gillen A, Riemondy K, Amani V, Griesinger A, Gilani A, Venkataraman S, et al.
Cell Rep
. 2020 Aug;
32(6):108023.
PMID: 32783945
Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding...
15.
Pierce A, Witt D, Donson A, Gilani A, Sanford B, Sill M, et al.
Neuro Oncol
. 2019 Jul;
21(12):1540-1551.
PMID: 31276586
Background: Treatment for pediatric posterior fossa group A (PFA) ependymoma with gain of chromosome 1q (1q+) has not improved over the past decade owing partially to lack of clinically relevant...
16.
Donson A, Amani V, Warner E, Griesinger A, Witt D, Mulcahy Levy J, et al.
Mol Cancer Ther
. 2018 Jun;
17(9):1984-1994.
PMID: 29925527
Children with ependymoma (EPN) are cured in less than 50% of cases, with little improvement in outcome over the last several decades. Chemotherapy has not affected survival in EPN, due...
17.
Nellan A, Rota C, Majzner R, Lester-McCully C, Griesinger A, Mulcahy Levy J, et al.
J Immunother Cancer
. 2018 May;
6(1):30.
PMID: 29712574
Background: Standard-of-care therapies for treating pediatric medulloblastoma have long-term side effects, even in children who are cured. One emerging modality of cancer therapy that could be equally effective without such...
18.
Witt D, Donson A, Amani V, Moreira D, Sanford B, Hoffman L, et al.
Pediatr Blood Cancer
. 2018 Jan;
65(5):e26960.
PMID: 29350470
Background: A desperate need for novel therapies in pediatric ependymoma (EPN) exists, as chemotherapy remains ineffective and radiotherapy often fails. EPN have significant infiltration of immune cells, which correlates with...
19.
Amani V, Donson A, Lummus S, Prince E, Griesinger A, Witt D, et al.
J Neuropathol Exp Neurol
. 2017 Sep;
76(7):595-604.
PMID: 28863455
Ependymoma (EPN) is a common brain tumor of childhood that, despite standard surgery and radiation therapy, has a relapse rate of 50%. Clinical trials have been unsuccessful in improving outcome...
20.
Donson A, Apps J, Griesinger A, Amani V, Witt D, Anderson R, et al.
J Neuropathol Exp Neurol
. 2017 Sep;
76(9):779-788.
PMID: 28859336
Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling...