Andrea M Chiariello
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Explore the profile of Andrea M Chiariello including associated specialties, affiliations and a list of published articles.
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46
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1209
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Recent Articles
1.
Fontana A, Tafuri F, Abraham A, Bianco S, Esposito A, Conte M, et al.
Biochem Soc Trans
. 2025 Feb;
53(1).
PMID: 39927819
Genome architecture is closely tied to essential biological functions, yet a complete understanding of the mechanisms governing DNA folding remains a significant challenge. Theoretical models based on polymer physics have...
2.
Fontana A, Bianco S, Tafuri F, Esposito A, Abraham A, Conte M, et al.
J Chem Phys
. 2025 Jan;
162(1).
PMID: 39745153
In the last years, it has been proved that some viruses are able to re-structure chromatin organization and alter the epigenomic landscape of the host genome. In addition, they are...
3.
Vercellone F, Chiariello A, Esposito A, Conte M, Abraham A, Fontana A, et al.
Physiology (Bethesda)
. 2024 Nov;
40(3).
PMID: 39601793
The spatial organization of chromatin within the eukaryotic nucleus is critical in regulating key cellular functions, such as gene expression, and its disruption can lead to disease. Advances in experimental...
4.
Szabo D, Franke V, Bianco S, Batiuk M, Paul E, Kukalev A, et al.
bioRxiv
. 2024 May;
PMID: 38766140
Midbrain dopamine neurons (DNs) respond to a first exposure to addictive drugs and play key roles in chronic drug usage. As the synaptic and transcriptional changes that follow an acute...
5.
Chiariello A, Abraham A, Bianco S, Esposito A, Fontana A, Vercellone F, et al.
Nat Commun
. 2024 May;
15(1):4014.
PMID: 38740770
SARS-CoV-2 can re-structure chromatin organization and alter the epigenomic landscape of the host genome, but the mechanisms that produce such changes remain unclear. Here, we use polymer physics to investigate...
6.
Pourmorady A, Bashkirova E, Chiariello A, Belagzhal H, Kodra A, Duffie R, et al.
Nature
. 2023 Dec;
625(7993):181-188.
PMID: 38123679
Olfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one of approximately 2,000 or more OR alleles. OR gene...
7.
Chiariello A, Abraham A, Bianco S, Esposito A, Vercellone F, Conte M, et al.
bioRxiv
. 2023 Aug;
PMID: 37546924
SARS-CoV-2 is able to re-structure chromatin organization and alters the epigenomic landscape of the host genome, though the mechanisms that produce such changes are still poorly understood. Here, we investigate...
8.
Conte M, Matteuzzi T, Esposito A, Chiariello A, Bianco S, Vercellone F, et al.
bioRxiv
. 2023 Jul;
PMID: 37503084
Extrachromosomal DNAs (ecDNAs) are found in the nucleus of an array of human cancer cells where they can form clusters that were associated to oncogene overexpression, as they carry genes...
9.
Beagrie R, Thieme C, Annunziatella C, Baugher C, Zhang Y, Schueler M, et al.
Nat Methods
. 2023 Jun;
20(7):1037-1047.
PMID: 37336949
Technology for measuring 3D genome topology is increasingly important for studying gene regulation, for genome assembly and for mapping of genome rearrangements. Hi-C and other ligation-based methods have become routine...
10.
Conte M, Chiariello A, Bianco S, Esposito A, Abraham A, Nicodemi M
Methods Mol Biol
. 2023 May;
2655:57-66.
PMID: 37212988
Human chromosomes have a complex 3D spatial organization in the cell nucleus, which comprises a hierarchy of physical interactions across genomic scales. Such an architecture serves important functional roles, as...