Andrea L Szymczak-Workman
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Explore the profile of Andrea L Szymczak-Workman including associated specialties, affiliations and a list of published articles.
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24
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1244
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Recent Articles
1.
Murter B, Robinson S, Banerjee H, Lau L, Uche U, Szymczak-Workman A, et al.
J Biol Chem
. 2024 Oct;
300(12):107930.
PMID: 39454954
The protein known as PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have...
2.
Murter B, Robinson S, Banerjee H, Lau L, Uche U, Szymczak-Workman A, et al.
bioRxiv
. 2024 May;
PMID: 38746242
The protein known as PI3K-interacting protein (PIK3IP1), or transmembrane inhibitor of PI3K (TrIP), is highly expressed by T cells and can modulate PI3K activity in these cells. Several studies have...
3.
Manandhar P, Szymczak-Workman A, Kane L
J Immunol
. 2023 Dec;
212(3):466-474.
PMID: 38108417
Tim-3 is a transmembrane protein that is best known for being highly expressed on terminally exhausted CD8+ T cells associated with chronic infection and tumors, although its expression is not...
4.
Gocher-Demske A, Cui J, Szymczak-Workman A, Vignali K, Latini J, Pieklo G, et al.
Nat Immunol
. 2023 Mar;
24(5):841-854.
PMID: 36928412
Regulatory T (T) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from immunopathology, via anti-inflammatory cytokines, inhibitor receptors and metabolic disruption. Here...
5.
Andrews L, Vignali K, Szymczak-Workman A, Burton A, Brunazzi E, Ngiow S, et al.
Immunity
. 2021 Sep;
54(10):2209-2217.e6.
PMID: 34551314
CD4 T cells share common developmental pathways with CD8 T cells, and upon maturation, CD4 T conventional T (Tconv) cells lack phenotypic markers that distinguish these cells from FoxP3 T...
6.
Banerjee H, Nieves-Rosado H, Kulkarni A, Murter B, McGrath K, Chandran U, et al.
Cell Rep
. 2021 Sep;
36(11):109699.
PMID: 34525351
Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs...
7.
Kataoka S, Manandhar P, Lee J, Workman C, Banerjee H, Szymczak-Workman A, et al.
Sci Signal
. 2021 Jun;
14(687).
PMID: 34131021
Expression of the transmembrane protein Tim-3 is increased on dysregulated T cells undergoing chronic activation, including during chronic infection and in solid tumors. Thus, Tim-3 is generally thought of as...
8.
Andrews L, Somasundaram A, Moskovitz J, Szymczak-Workman A, Liu C, Cillo A, et al.
Sci Immunol
. 2020 Jul;
5(49).
PMID: 32680952
Mechanisms of resistance to cancer immunotherapy remain poorly understood. Lymphocyte activation gene-3 (LAG3) signaling is regulated by a disintegrin and metalloprotease domain-containing protein-10 (ADAM10)- and ADAM17-mediated cell surface shedding. Here,...
9.
Liu C, Somasundaram A, Manne S, Gocher A, Szymczak-Workman A, Vignali K, et al.
Nat Immunol
. 2020 Jul;
21(9):1010-1021.
PMID: 32661362
Robust CD8 T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint...
10.
Sullivan J, Tomita Y, Jankowska-Gan E, Lema D, Arvedson M, Nair A, et al.
Cell Rep
. 2020 Jan;
30(4):1039-1051.e5.
PMID: 31995748
Interleukin-35 (IL-35) is an immunosuppressive cytokine composed of Epstein-Barr-virus-induced protein 3 (Ebi3) and IL-12α chain (p35) subunits, yet the forms that IL-35 assume and its role in peripheral tolerance remain...