Andrea J Lee
Overview
Explore the profile of Andrea J Lee including associated specialties, affiliations and a list of published articles.
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15
Citations
211
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Recent Articles
1.
Lee A, Majumdar C, Kathe S, Van Ostrand R, Vickery H, Averill A, et al.
J Am Chem Soc
. 2020 Jul;
142(31):13283-13287.
PMID: 32664726
MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mutations. Successful repair requires MutY recognition of...
2.
Michalski J, Lyden E, Lee A, Al-Kadhimi Z, Maness L, Gundabolu K, et al.
Future Oncol
. 2019 Jun;
15(17):1989-1995.
PMID: 31170814
This study evaluated the overall survival (OS) of older patients (≥60 years) with acute myeloid leukemia based on the intensity of treatment. This single center, retrospective study included 211 patients...
3.
Nelson S, Kathe S, Hilzinger T, Averill A, Warshaw D, Wallace S, et al.
Nucleic Acids Res
. 2019 Jan;
47(6):3058-3071.
PMID: 30698731
Proper repair of oxidatively damaged DNA bases is essential to maintain genome stability. 8-Oxoguanine (7,8-dihydro-8-oxoguanine, 8-oxoG) is a dangerous DNA lesion because it can mispair with adenine (A) during replication...
4.
Lee A, Wallace S
Free Radic Biol Med
. 2016 Nov;
107:170-178.
PMID: 27865982
The first step of the base excision repair (BER) pathway responsible for removing oxidative DNA damage utilizes DNA glycosylases to find and remove the damaged DNA base. How glycosylases find...
5.
Lee A, Wallace S
Radiat Phys Chem Oxf Engl 1993
. 2016 Nov;
128:126-133.
PMID: 27818579
The Base Excision Repair (BER) pathway removes the vast majority of damages produced by ionizing radiation, including the plethora of radiation-damaged purines and pyrimidines. The first enzymes in the BER...
6.
Lee A, Warshaw D, Wallace S
DNA Repair (Amst)
. 2014 Feb;
20:23-31.
PMID: 24560296
The first step of base excision repair utilizes glycosylase enzymes to find damage within a genome. A persistent question in the field of DNA repair is how glycosylases interact with...
7.
Lee A, Asher W, Stern H, Bren K, Krauss T
J Phys Chem Lett
. 2013 Oct;
4(16):2727-2733.
PMID: 24116268
Conformational dynamics of proteins are important for function. However, obtaining information about specific conformations is difficult for samples displaying heterogeneity. Here, time-resolved fluorescence resonance energy transfer is used to characterize...
8.
Lee A, Wang X, Carlson L, Smyder J, Loesch B, Tu X, et al.
Nano Lett
. 2011 Mar;
11(4):1636-40.
PMID: 21417364
Single-walled carbon nanotubes (SWNTs) have unique photophysical properties but low fluorescence efficiency. We have found significant increases in the fluorescence efficiency of individual DNA-wrapped SWNTs upon addition of reducing agents,...
9.
Lee A, Ensign A, Krauss T, Bren K
J Am Chem Soc
. 2010 Jan;
132(6):1752-3.
PMID: 20102193
We demonstrate that Zn(II) porphyrin in Zn(II)cytochrome c (Zn cyt c) is a fluorescence resonance energy transfer (FRET) donor to an Alexa660 dye acceptor. The energy transfer efficiency is dependent...
10.
Ostrowski A, Deakin S, Azhar B, Miller T, Franco N, Cherney M, et al.
J Med Chem
. 2009 Dec;
53(2):715-22.
PMID: 19950902
The chromium(III) nitrito complex trans-Cr(cyclam)(ONO)(2)(+) (1) is a very promising photochemical precursor for nitric oxide delivery to physiological targets. Here, we demonstrate that visible wavelength excitation of 1 in solutions...