Andrea DOsualdo
Overview
Explore the profile of Andrea DOsualdo including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
647
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Recent Articles
1.
Hempel A, DOsualdo A, Snipas S, Salvesen G
Biosci Rep
. 2023 Oct;
43(10).
PMID: 37797233
Many proinflammatory proteins are released via the necrotic form of cell death known as pyroptosis. Sometimes known as gasdermin D (GSDMD) dependent cell death, pyroptosis results from the formation of...
2.
Richter K, Rufer A, Muller M, Burger D, Casagrande F, Grossenbacher T, et al.
J Biol Chem
. 2020 Jul;
295(29):10077.
PMID: 32680972
No abstract available.
3.
Richter K, Rufer A, Muller M, Burger D, Casagrande F, Grossenbacher T, et al.
J Biol Chem
. 2020 Apr;
295(23):7849-7864.
PMID: 32317279
Activation of the T cell receptor (TCR) results in binding of the adapter protein Nck (noncatalytic region of tyrosine kinase) to the CD3ϵ subunit of the TCR. The interaction was...
4.
Zhong F, Robinson K, Teo D, Tan K, Lim C, Harapas C, et al.
J Biol Chem
. 2018 Oct;
293(49):18864-18878.
PMID: 30291141
The inflammasome is a critical molecular complex that activates interleukin-1 driven inflammation in response to pathogen- and danger-associated signals. Germline mutations in the inflammasome sensor NLRP1 cause Mendelian systemic autoimmunity...
5.
Gasteiger G, DOsualdo A, Schubert D, Weber A, Bruscia E, Hartl D
J Innate Immun
. 2016 Dec;
9(2):111-125.
PMID: 28006777
Innate immunity is a rapidly evolving field with novel cell types and molecular pathways being discovered and paradigms changing continuously. Innate and adaptive immune responses are traditionally viewed as separate...
6.
DOsualdo A, Anania V, Yu K, Lill J, Kaufman R, Matsuzawa S, et al.
PLoS One
. 2015 Jun;
10(6):e0130635.
PMID: 26086088
Perturbation of endoplasmic reticulum (ER) homeostasis triggers the ER stress response (also known as Unfolded Protein Response), a hallmark of many pathological disorders. However the connection between ER stress and...
7.
Bachetti T, Chiesa S, Castagnola P, Bani D, Di Zanni E, Omenetti A, et al.
Ann Rheum Dis
. 2012 Nov;
72(6):1044-52.
PMID: 23117241
Objectives: Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is caused by TNFRSF1A mutations, known to induce intracellular retention of the TNFα receptor 1 (TNFR1) protein, defective TNFα-induced apoptosis, and...
8.
DOsualdo A, Reed J
Pigment Cell Melanoma Res
. 2011 Nov;
25(1):5-8.
PMID: 22117610
Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here, we review what is currently known about the mechanisms...
9.
DOsualdo A, Weichenberger C, Wagner R, Godzik A, Wooley J, Reed J
PLoS One
. 2011 Nov;
6(11):e27396.
PMID: 22087307
The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein complexes responsible for activation of caspase-1, a regulator of...
10.
Gattorno M, Tassi S, Carta S, Delfino L, Ferlito F, Pelagatti M, et al.
Arthritis Rheum
. 2007 Sep;
56(9):3138-48.
PMID: 17763411
Objective: To examine the synthesis, processing, and secretion of interleukin-1beta (IL-1beta), as well as the clinical and biologic effects of IL-1 blockade, in patients with chronic infantile neurologic, cutaneous, articular...