NLRP1, a Regulator of Innate Immunity Associated with Vitiligo

Overview

Journal Pigment Cell Melanoma Res

Date 2011 Nov 29

PMID 22117610

Citations 10

Authors

Andrea DOsualdo

John C Reed

Affiliations

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Abstract

Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here, we review what is currently known about the mechanisms that regulate activation of the NLRP1 protein and the downstream effects of NLRP1 on pathways impacting inflammation and apoptosis. How polymorphic variants of the NLRP1 gene contribute to the pathogenesis of vitiligo remains mysterious, requiring further investigation.

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