Andrea Decker
Overview
Explore the profile of Andrea Decker including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
459
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0
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Recent Articles
1.
Ferretti S, Hamon J, de Kanter R, Scheufler C, Andraos-Rey R, Barbe S, et al.
Nature
. 2024 Apr;
629(8011):443-449.
PMID: 38658754
The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal target in cancer cells with microsatellite instability (MSI) by several genetic screens. Despite advances in treatment with immune...
2.
Thoma G, Decoret O, Vangrevelinghe E, Trunzer M, Decker A, Leon A, et al.
J Med Chem
. 2023 Oct;
66(21):15042-15053.
PMID: 37906573
We describe the discovery and characterization of the supersoft topical JAK inhibitor , which is potent in biochemical and cellular assays as well as in human skin models. In blood,...
3.
Schweininger J, Kriegel M, Hage S, Conrad M, Alkhashrom S, Losing J, et al.
J Biol Chem
. 2022 Jan;
298(3):101625.
PMID: 35074430
Varicella-zoster virus (VZV) is a human pathogen from the α-subfamily of herpesviruses. The VZV Orf24-Orf27 complex represents the essential viral core nuclear egress complex (NEC) that orchestrates the egress of...
4.
Auberson Y, Brocklehurst C, Furegati M, Fessard T, Koch G, Decker A, et al.
ChemMedChem
. 2017 Mar;
12(8):590-598.
PMID: 28319646
Bicycloalkyl groups have been previously described as phenyl group bioisosteres. This article describes the synthesis of new building blocks allowing their introduction into complex molecules, and explores their use as...
5.
Kuemin C, Cathrein Huckstadt K, Lortscher E, Rey A, Decker A, Spencer N, et al.
Adv Mater
. 2010 May;
22(25):2804-8.
PMID: 20432224
No abstract available.
6.
Solomon E, Wong S, Liu L, Decker A, Chow M
Curr Opin Chem Biol
. 2009 Mar;
13(1):99-113.
PMID: 19278895
Fe(III)OOH and Fe(IV)O intermediates have now been documented in a number of nonheme iron active sites. In this Current Opinion we use spectroscopy combined with electronic structure calculations to define...
7.
Decker A, Rohde J, Klinker E, Wong S, Que Jr L, Solomon E
J Am Chem Soc
. 2007 Dec;
129(51):15983-96.
PMID: 18052249
High-valent FeIV=O species are key intermediates in the catalytic cycles of many mononuclear non-heme iron enzymes and have been structurally defined in model systems. Variable-temperature magnetic circular dichroism (VT-MCD) spectroscopy...
8.
Neidig M, Decker A, Choroba O, Huang F, Kavana M, Moran G, et al.
Proc Natl Acad Sci U S A
. 2006 Aug;
103(35):12966-73.
PMID: 16920789
(4-Hydroxy)mandelate synthase (HmaS) and (4-hydroxyphenyl)pyruvate dioxygenase (HPPD) are two alpha-keto acid dependent mononuclear non-heme iron enzymes that use the same substrate, (4-hydroxyphenyl)pyruvate, but exhibit two different general reactivities. HmaS performs...
9.
Decker A, Chow M, Kemsley J, Lehnert N, Solomon E
J Am Chem Soc
. 2006 Apr;
128(14):4719-33.
PMID: 16594709
Bleomycin (BLM), a glycopeptide antibiotic chemotherapy agent, is capable of single- and double-strand DNA damage. Activated bleomycin (ABLM), a low-spin Fe(III)-OOH complex, is the last intermediate detected prior to DNA...
10.
Decker A, Clay M, Solomon E
J Inorg Biochem
. 2006 Mar;
100(4):697-706.
PMID: 16510189
High-valent iron-oxo intermediates are known or believed to be key oxidizing species in the catalytic mechanisms of many mononuclear and binuclear non-heme iron enzymes. So far only limited experimental data...