Andrea DAmbrogio
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Explore the profile of Andrea DAmbrogio including associated specialties, affiliations and a list of published articles.
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10
Citations
1781
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Recent Articles
1.
Sugimoto Y, Vigilante A, Darbo E, Zirra A, Militti C, DAmbrogio A, et al.
Nature
. 2015 Mar;
519(7544):491-4.
PMID: 25799984
The structure of messenger RNA is important for post-transcriptional regulation, mainly because it affects binding of trans-acting factors. However, little is known about the in vivo structure of full-length mRNAs....
2.
Huppertz I, Attig J, DAmbrogio A, Easton L, Sibley C, Sugimoto Y, et al.
Methods
. 2013 Nov;
65(3):274-87.
PMID: 24184352
RNA-binding proteins (RBPs) are key players in the post-transcriptional regulation of gene expression. Precise knowledge about their binding sites is therefore critical to unravel their molecular function and to understand...
3.
DAmbrogio A, Nagaoka K, Richter J
Nat Rev Cancer
. 2013 Mar;
13(4):283-90.
PMID: 23446545
The cytoplasmic polyadenylation element binding proteins (CPEBs) associate with specific sequences in mRNA 3' untranslated regions to promote translation. They do so by inducing cytoplasmic polyadenylation, which requires specialized poly(A)...
4.
DAmbrogio A, Gu W, Udagawa T, Mello C, Richter J
Cell Rep
. 2012 Dec;
2(6):1537-45.
PMID: 23200856
MicroRNAs (miRNAs) are small, noncoding RNAs that inhibit translation and promote mRNA decay. The levels of mature miRNAs are the result of different rates of transcription, processing, and turnover. The...
5.
Burns D, DAmbrogio A, Nottrott S, Richter J
Nature
. 2011 Apr;
473(7345):105-8.
PMID: 21478871
Cytoplasmic polyadenylation-induced translation controls germ cell development, neuronal synaptic plasticity and cellular senescence, a tumour-suppressor mechanism that limits the replicative lifespan of cells. The cytoplasmic polyadenylation element binding protein (CPEB)...
6.
Ayala Y, De Conti L, Avendano-Vazquez S, Dhir A, Romano M, DAmbrogio A, et al.
EMBO J
. 2010 Dec;
30(2):277-88.
PMID: 21131904
TAR DNA-binding protein (TDP-43) is an evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) involved in RNA processing, whose abnormal cellular distribution and post-translational modification are key markers of certain neurodegenerative diseases,...
7.
DAmbrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala Y, et al.
Nucleic Acids Res
. 2009 May;
37(12):4116-26.
PMID: 19429692
Nuclear factor TDP-43 has been reported to play multiple roles in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. From a structural point of view, TDP-43 is a member of...
8.
Feiguin F, Godena V, Romano G, DAmbrogio A, Klima R, Baralle F
FEBS Lett
. 2009 Apr;
583(10):1586-92.
PMID: 19379745
Pathological modifications in the highly conserved and ubiquitously expressed heterogeneous ribonucleoprotein TDP-43 were recently associated to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a late-onset disorder that affects predominantly motoneurons...
9.
Ayala Y, Zago P, DAmbrogio A, Xu Y, Petrucelli L, Buratti E, et al.
J Cell Sci
. 2008 Oct;
121(Pt 22):3778-85.
PMID: 18957508
TDP-43 (also known as TARDBP) regulates different processes of gene expression, including transcription and splicing, through RNA and DNA binding. Moreover, recent reports have shown that the protein interacts with...
10.
Ayala Y, Pantano S, DAmbrogio A, Buratti E, Brindisi A, Marchetti C, et al.
J Mol Biol
. 2005 Apr;
348(3):575-88.
PMID: 15826655
TAR DNA binding protein (TDP43), a highly conserved heterogeneous nuclear ribonucleoprotein, was found to down-regulate splicing of the exon 9 cystic fibrosis transmembrane conductance regulator (CFTR) through specific binding to...