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Andre M Pilon

Explore the profile of Andre M Pilon including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 209
Followers 0
Related Specialties
Pharmacology
Cell Biology
Hematology
Top 10 Co-Authors
David M Bodine
Patrick G Gallagher
John C McKew
Jose Sangerman
Gilda F Linton
Weiming Li
Gurmit Grewal
Elliott H Margulies
Subramanian S Ajay
Wei Zheng
Published In
Blood
Mol Cell Biol
Pharmaceut Med
Br J Pharmacol
Trends Pharmacol Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism
Krishnan V, Ma Y, Chen C, Thorne N, Bullock H, Tawa G, et al.
Br J Pharmacol . 2017 Sep; 175(2):262-271. PMID: 28898923
Background And Purpose: Human parathyroid hormone (PTH) is critical for maintaining physiological calcium homeostasis and plays an important role in the formation and maintenance of the bone. Full-length PTH and...
2.
New Financial and Research Models for Pediatric Orphan Drug Development - Focus on the NCATS TRND Program
Shen J, Grewal G, Pilon A, McKew J
Pharmaceut Med . 2014 May; 28(1):1-6. PMID: 24855373
While there are approximately 7,000 identified human diseases considered as "rare" based on population prevalence or incidence, the cumulative impact runs into the millions of patients globally. Although the genetic...
3.
NIH TRND program: successes in preclinical therapeutic development
McKew J, Pilon A
Trends Pharmacol Sci . 2012 Nov; 34(2):87-9. PMID: 23174531
No abstract available.
4.
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation
Pilon A, Ajay S, Kumar S, Steiner L, Cherukuri P, Wincovitch S, et al.
Blood . 2011 Sep; 118(17):e139-48. PMID: 21900194
Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel sequencing (ChIP-Seq) is a powerful, unbiased method to map...
5.
Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2
Pilon A, Arcasoy M, Dressman H, Vayda S, Maksimova Y, Sangerman J, et al.
Mol Cell Biol . 2008 Oct; 28(24):7394-401. PMID: 18852285
Erythroid Krüppel-like factor (EKLF) is a Krüppel-like transcription factor identified as a transcriptional activator and chromatin modifier in erythroid cells. EKLF-deficient (Eklf(-/-)) mice die at day 14.5 of gestation from...
6.
Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice
Pilon A, Nilson D, Zhou D, Sangerman J, Townes T, Bodine D, et al.
Mol Cell Biol . 2006 May; 26(11):4368-77. PMID: 16705186
Erythroid Krüppel-like factor (EKLF) is an erythroid zinc finger protein identified by its interaction with a CACCC sequence in the beta-globin promoter, where it establishes local chromatin structure permitting beta-globin...
7.
Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells
Brenner S, Whiting-Theobald N, Linton G, Holmes K, Anderson-Cohen M, Kelly P, et al.
Blood . 2003 Jun; 102(8):2789-97. PMID: 12829597
In previous studies amphotropic MFGS-gp91phox (murine onco-retrovirus vector) was used in a clinical trial of X-linked chronic granulomatous disease (X-CGD) gene therapy to achieve transient correction of oxidase activity in...