Andre J Faure
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Explore the profile of Andre J Faure including associated specialties, affiliations and a list of published articles.
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19
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Recent Articles
1.
Faure A, Lehner B
Genome Biol
. 2024 Dec;
25(1):303.
PMID: 39617885
We present MoCHI, a tool to fit interpretable models using deep mutational scanning data. MoCHI infers free energy changes, as well as interaction terms (energetic couplings) for specified biophysical models,...
2.
Bendel A, Faure A, Klein D, Shimada K, Lyautey R, Schiffelholz N, et al.
Nat Commun
. 2024 Oct;
15(1):8868.
PMID: 39402041
The encoding and evolution of specificity and affinity in protein-protein interactions is poorly understood. Here, we address this question by quantifying how all mutations in one protein, JUN, alter binding...
3.
Faure A, Marti-Aranda A, Hidalgo-Carcedo C, Beltran A, Schmiedel J, Lehner B
Nature
. 2024 Sep;
634(8035):995-1003.
PMID: 39322666
There are more ways to synthesize a 100-amino acid (aa) protein (20) than there are atoms in the universe. Only a very small fraction of such a vast sequence space...
4.
Arutyunyan A, Seuma M, Faure A, Bolognesi B, Lehner B
bioRxiv
. 2024 Aug;
PMID: 39091732
Amyloid protein aggregates are pathological hallmarks of more than fifty human diseases but how soluble proteins nucleate to form amyloids is poorly understood. Here we use combinatorial mutagenesis, a kinetic...
5.
Faure A, Lehner B, Miro Pina V, Serrano Colome C, Weghorn D
PLoS Comput Biol
. 2024 May;
20(5):e1012132.
PMID: 38805561
Accurate models describing the relationship between genotype and phenotype are necessary in order to understand and predict how mutations to biological sequences affect the fitness and evolution of living organisms....
6.
Weng C, Faure A, Escobedo A, Lehner B
Nature
. 2023 Dec;
626(7999):643-652.
PMID: 38109937
Thousands of proteins have been validated genetically as therapeutic targets for human diseases. However, very few have been successfully targeted, and many are considered 'undruggable'. This is particularly true for...
7.
Faure A, Domingo J, Schmiedel J, Hidalgo-Carcedo C, Diss G, Lehner B
Nature
. 2022 Apr;
604(7904):175-183.
PMID: 35388192
Allosteric communication between distant sites in proteins is central to biological regulation but still poorly characterized, limiting understanding, engineering and drug development. An important reason for this is the lack...
8.
Soo V, Swadling J, Faure A, Warnecke T
PLoS Genet
. 2021 Feb;
17(2):e1009353.
PMID: 33524037
RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which...
9.
Seuma M, Faure A, Badia M, Lehner B, Bolognesi B
Elife
. 2021 Feb;
10.
PMID: 33522485
Plaques of the amyloid beta (Aß) peptide are a pathological hallmark of Alzheimer's disease (AD), the most common form of dementia. Mutations in Aß also cause familial forms of AD...
10.
Faure A, Schmiedel J, Baeza-Centurion P, Lehner B
Genome Biol
. 2020 Aug;
21(1):207.
PMID: 32799905
Deep mutational scanning (DMS) enables multiplexed measurement of the effects of thousands of variants of proteins, RNAs, and regulatory elements. Here, we present a customizable pipeline, DiMSum, that represents an...