Anders Holmgaard Hansen
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Explore the profile of Anders Holmgaard Hansen including associated specialties, affiliations and a list of published articles.
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15
Citations
152
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Recent Articles
1.
Hefzi H, Martinez-Monge I, Marin de Mas I, Cowie N, Gomez Toledo A, Noh S, et al.
Nat Metab
. 2025 Jan;
7(1):212-227.
PMID: 39809975
The Warburg effect, which describes the fermentation of glucose to lactate even in the presence of oxygen, is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for...
2.
Hefzi H, Martinez-Monge I, Marin de Mas I, Cowie N, Gomez Toledo A, Noh S, et al.
bioRxiv
. 2024 Aug;
PMID: 39211256
The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to...
3.
Li H, Peralta A, Schoffelen S, Hansen A, Arnsdorf J, Schinn S, et al.
bioRxiv
. 2024 Apr;
PMID: 38585977
Glycosylation affects many vital functions of organisms. Therefore, its surveillance is critical from basic science to biotechnology, including biopharmaceutical development and clinical diagnostics. However, conventional glycan structure analysis faces challenges...
4.
Kotidis P, Donini R, Arnsdorf J, Hansen A, Voldborg B, Chiang A, et al.
Metab Eng
. 2023 Jan;
76:87-96.
PMID: 36610518
Chinese hamster ovary (CHO) cells are extensively used for the production of glycoprotein therapeutics proteins, for which N-linked glycans are a critical quality attribute due to their influence on activity...
5.
Anyaogu D, Hansen A, Hoof J, Majewska N, Contesini F, Paul J, et al.
Metab Eng
. 2021 Jun;
67:153-163.
PMID: 34174425
Filamentous fungi secrete protein with a very high efficiency, and this potential can be exploited advantageously to produce therapeutic proteins at low costs. A significant barrier to this goal is...
6.
Kol S, Ley D, Wulff T, Decker M, Arnsdorf J, Schoffelen S, et al.
Nat Commun
. 2020 Apr;
11(1):1908.
PMID: 32313013
Host cell proteins (HCPs) are process-related impurities generated during biotherapeutic protein production. HCPs can be problematic if they pose a significant metabolic demand, degrade product quality, or contaminate the final...
7.
Ha T, Hansen A, Kildegaard H, Lee G
Metab Eng
. 2019 Dec;
57:182-192.
PMID: 31785386
Sialic acid, a terminal monosaccharide present in N-glycans, plays an important role in determining both the in vivo half-life and the therapeutic efficacy of recombinant glycoproteins. Low sialylation levels of...
8.
Karottki K, Hefzi H, Xiong K, Shamie I, Hansen A, Li S, et al.
Biotechnol Bioeng
. 2019 Oct;
117(2):593-598.
PMID: 31631317
Chinese hamster ovary (CHO) cells are the preferred workhorse for the biopharmaceutical industry, and CRISPR/Cas9 has proven powerful for generating targeted gene perturbations in CHO cells. Here, we expand the...
9.
Amann T, Hansen A, Kol S, Hansen H, Arnsdorf J, Nallapareddy S, et al.
Metab Eng
. 2018 Dec;
52:143-152.
PMID: 30513349
Recombinant Chinese hamster ovary (CHO) cells are able to provide biopharmaceuticals that are essentially free of human viruses and have N-glycosylation profiles similar, but not identical, to humans. Due to...
10.
Amann T, Hansen A, Kol S, Lee G, Andersen M, Kildegaard H
Biotechnol J
. 2018 Jun;
13(10):e1800111.
PMID: 29862652
In production of recombinant proteins for biopharmaceuticals, N-glycosylation is often important for protein efficacy and patient safety. IgG with agalactosylated (G0)-N-glycans can improve the activation of the lectin-binding complement system...