Anastasiya Boltengagen
Overview
Explore the profile of Anastasiya Boltengagen including associated specialties, affiliations and a list of published articles.
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17
Citations
646
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Recent Articles
1.
Schneeberger S, Kim S, Geesdorf M, Friebel E, Eede P, Jendrach M, et al.
Nat Aging
. 2025 Mar;
PMID: 40082619
Neuroinflammation including interleukin (IL)-12/IL-23-signaling is central to Alzheimer's disease (AD) pathology. Inhibition of p40, a subunit of IL-12/IL-23, attenuates pathology in AD-like mice; however, its signaling mechanism and expression pattern...
2.
Schott M, Leon-Perinan D, Splendiani E, Strenger L, Licha J, Pentimalli T, et al.
Cell
. 2024 Jun;
187(15):3953-3972.e26.
PMID: 38917789
Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue development, homeostasis, or disease. However, there is a need for easy-to-use, high-resolution, cost-efficient, and 3D-scalable methods. Here, we report Open-ST, a...
3.
Liu H, Arsie R, Schwabe D, Schilling M, Minia I, Alles J, et al.
Mol Syst Biol
. 2024 May;
19(10):1-23.
PMID: 38778223
RNA abundance is tightly regulated in eukaryotic cells by modulating the kinetic rates of RNA production, processing, and degradation. To date, little is known about time‐dependent kinetic rates during dynamic...
4.
Wandres M, Aigner D, Kastelic N, Boltengagen A, Rybak-Wolf A, Rajewsky N
J Vis Exp
. 2024 Apr;
(205).
PMID: 38619271
Over the past decade, single-cell transcriptomics has significantly evolved and become a standard laboratory method for simultaneous analysis of gene expression profiles of individual cells, allowing the capture of cellular...
5.
Legnini I, Emmenegger L, Zappulo A, Rybak-Wolf A, Wurmus R, Martinez A, et al.
Nat Methods
. 2023 Sep;
20(10):1544-1552.
PMID: 37735569
Organoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of...
6.
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
Hinze C, Kocks C, Leiz J, Karaiskos N, Boltengagen A, Cao S, et al.
Genome Med
. 2022 Sep;
14(1):103.
PMID: 36085050
Background: Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood....
7.
Klocke J, Kim S, Skopnik C, Hinze C, Boltengagen A, Metzke D, et al.
Kidney Int
. 2022 Sep;
102(6):1359-1370.
PMID: 36049643
Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI remain incompletely understood,...
8.
Leiz J, Hinze C, Boltengagen A, Braeuning C, Kocks C, Rajewsky N, et al.
J Vis Exp
. 2021 Oct;
(175).
PMID: 34605813
The kidneys regulate diverse biological processes such as water, electrolyte, and acid-base homeostasis. Physiological functions of the kidney are executed by multiple cell types arranged in a complex architecture across...
9.
Hinze C, Karaiskos N, Boltengagen A, Walentin K, Redo K, Himmerkus N, et al.
J Am Soc Nephrol
. 2020 Nov;
32(2):291-306.
PMID: 33239393
Background: Single-cell transcriptomes from dissociated tissues provide insights into cell types and their gene expression and may harbor additional information on spatial position and the local microenvironment. The kidney's cells...
10.
Marg A, Escobar H, Karaiskos N, Grunwald S, Metzler E, Kieshauer J, et al.
Nat Commun
. 2019 Dec;
10(1):5776.
PMID: 31852888
Skeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7, are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to utilize the regenerative potential of...