Ailong Ke
Overview
Explore the profile of Ailong Ke including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
67
Citations
2202
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Yan H, Tan X, Zou S, Sun Y, Ke A, Tang W
Nat Chem Biol
. 2024 Jul;
20(12):1617-1628.
PMID: 38977787
OMEGA RNA (ωRNA)-guided endonuclease IscB, the evolutionary ancestor of Cas9, is an attractive system for in vivo genome editing because of its compact size and mechanistic resemblance to Cas9. However,...
2.
Hu C, Myers M, Zhou X, Hou Z, Lozen M, Nam K, et al.
Mol Cell
. 2024 Jan;
84(3):463-475.e5.
PMID: 38242128
Type I CRISPR-Cas systems utilize the RNA-guided Cascade complex to identify matching DNA targets and the nuclease-helicase Cas3 to degrade them. Among the seven subtypes, type I-C is compact in...
3.
Hu C, Myers M, Zhou X, Hou Z, Lozen M, Zhang Y, et al.
bioRxiv
. 2023 Aug;
PMID: 37577534
Type I CRISPR-Cas systems utilize the RNA-guided Cascade complex to identify matching DNA targets, and the nuclease-helicase Cas3 to degrade them. Among seven subtypes, Type I-C is compact in size...
4.
Park J, Petassi M, Hsieh S, Mehrotra E, Schuler G, Budhathoki J, et al.
Mol Cell
. 2023 Jun;
83(11):1827-1838.e6.
PMID: 37267904
CRISPR-associated transposons (CASTs) are natural RNA-directed transposition systems. We demonstrate that transposon protein TniQ plays a central role in promoting R-loop formation by RNA-guided DNA-targeting modules. TniQ residues, proximal to...
5.
Hu C, van Beljouw S, Nam K, Schuler G, Ding F, Cui Y, et al.
Science
. 2022 Aug;
377(6612):1278-1285.
PMID: 36007061
The CRISPR-Cas type III-E RNA-targeting effector complex gRAMP/Cas7-11 is associated with a caspase-like protein (TPR-CHAT/Csx29) to form Craspase (CRISPR-guided caspase). Here, we use cryo-electron microscopy snapshots of Craspase to explain...
6.
Hu C, Ke A
Methods Enzymol
. 2022 Aug;
673:405-424.
PMID: 35965014
Type I is the most prevalent CRISPR system found in nature. It can be further defined into six subtypes, from I-A to I-G. Among them, the Type I-A CRISPR-Cas systems...
7.
Hu C, Ni D, Nam K, Majumdar S, McLean J, Stahlberg H, et al.
Mol Cell
. 2022 Jul;
82(15):2754-2768.e5.
PMID: 35835111
Type I CRISPR-Cas systems typically rely on a two-step process to degrade DNA. First, an RNA-guided complex named Cascade identifies the complementary DNA target. The helicase-nuclease fusion enzyme Cas3 is...
8.
Schuler G, Hu C, Ke A
Science
. 2022 May;
376(6600):1476-1481.
PMID: 35617371
Class 2 CRISPR effectors Cas9 and Cas12 may have evolved from nucleases in IS200/IS605 transposons. IscB is about two-fifths the size of Cas9 but shares a similar domain organization. The...
9.
Hou Z, Hu C, Ke A, Zhang Y
Curr Protoc
. 2022 Feb;
2(2):e361.
PMID: 35129865
CRISPR-Cas systems provide researchers with eukaryotic genome editing tools and therapeutic platforms that make it possible to target disease mutations in somatic organs. Most of these tools employ Type II...
10.
Tan R, Krueger R, Gramelspacher M, Zhou X, Xiao Y, Ke A, et al.
Mol Cell
. 2022 Jan;
82(4):852-867.e5.
PMID: 35051351
Leading CRISPR-Cas technologies employ Cas9 and Cas12 enzymes that generate RNA-guided dsDNA breaks. Yet, the most abundant microbial adaptive immune systems, Type I CRISPRs, are under-exploited for eukaryotic applications. Here,...