Amy E Medlock
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Explore the profile of Amy E Medlock including associated specialties, affiliations and a list of published articles.
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25
Citations
515
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Recent Articles
1.
Dailey H, Medlock A
Methods Mol Biol
. 2024 Jul;
2839:243-247.
PMID: 39008258
Ferrochelatases (E.C. 4.99.1.1) catalyze the insertion of ferrous iron into either protoporphyrin IX to make protoheme IX or coproporphyrin III to make coproheme III. Ferrochelatase activity in extracts or purified...
2.
Guo M, Lin Y, Obi C, Zhao P, Dailey H, Medlock A, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928065
Ferrochelatase (FECH) is the terminal enzyme in human heme biosynthesis, catalyzing the insertion of ferrous iron into protoporphyrin IX (PPIX) to form protoheme IX (Heme). Phosphorylation increases the activity of...
3.
Hesse D, Ramsey L, Bruner L, Vega-Castillo C, Teshager D, Hill J, et al.
Med Sci Educ
. 2023 Jun;
33(2):353-357.
PMID: 37261018
Gender gaps in academic performance have been reported at a variety of educational levels including several national standardized exams for medical education, with men scoring higher than women. These gaps...
4.
Obi C, Dailey H, Jami-Alahmadi Y, Wohlschlegel J, Medlock A
Life (Basel)
. 2023 Feb;
13(2).
PMID: 36836934
Heme is an essential cofactor for multiple cellular processes in most organisms. In developing erythroid cells, the demand for heme synthesis is high, but is significantly lower in non-erythroid cells....
5.
Dailey H, Medlock A
Biol Chem
. 2022 Aug;
403(11-12):985-1003.
PMID: 36029525
Heme (protoheme IX) is an essential cofactor for a large variety of proteins whose functions vary from one electron reactions to binding gases. While not ubiquitous, heme is found in...
6.
Medlock A, Dailey H
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806474
During erythropoiesis, there is an enormous demand for the synthesis of the essential cofactor of hemoglobin, heme. Heme is synthesized de novo via an eight enzyme-catalyzed pathway within each developing...
7.
Medlock A, Hixon J, Bhuiyan T, Cobine P
Front Cell Dev Biol
. 2022 Jun;
10:892325.
PMID: 35669513
Metals are key elements for the survival and normal development of humans but can also be toxic to cells when mishandled. In fact, even mild disruption of metal homeostasis causes...
8.
Obi C, Bhuiyan T, Dailey H, Medlock A
Front Cell Dev Biol
. 2022 Jun;
10:894591.
PMID: 35646904
Porphyrin and iron are ubiquitous and essential for sustaining life in virtually all living organisms. Unlike iron, which exists in many forms, porphyrin macrocycles are mostly functional as metal complexes....
9.
Weerth R, Medlock A, Dailey H
J Biol Chem
. 2021 Sep;
297(5):101017.
PMID: 34582890
Heme, a near ubiquitous cofactor, is synthesized by most organisms. The essential step of insertion of iron into the porphyrin macrocycle is mediated by the enzyme ferrochelatase. Several ferrochelatases have...
10.
Dietz J, Willoughby M, Piel 3rd R, Ross T, Bohovych I, Addis H, et al.
Redox Biol
. 2021 Sep;
46:102125.
PMID: 34517185
Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the...