Amy E Brix
Overview
Explore the profile of Amy E Brix including associated specialties, affiliations and a list of published articles.
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20
Citations
451
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Recent Articles
1.
Dunnick J, Shockley K, Morgan D, Travlos G, Gerrish K, Ton T, et al.
Toxicol Pathol
. 2019 Dec;
48(2):338-349.
PMID: 31826744
Human exposure to pentabromodiphenyl ether (PBDE) mixture (DE-71) and its PBDE-47 congener can occur both in utero and during lactation. Here, we tested the hypothesis that PBDE-induced neonatal hepatic transcriptomic...
2.
Sills R, Cesta M, Willson C, Brix A, Berridge B
Toxicol Pathol
. 2019 Sep;
47(7):887-890.
PMID: 31522628
The National Toxicology Program (NTP) uses histopathological evaluation of animal tissues as a key element in its toxicity and carcinogenicity studies. The initial histopathological evaluations are subjected to a rigorous...
3.
Filgo A, Quist E, Hoenerhoff M, Brix A, Kissling G, Fenton S
Toxicol Pathol
. 2014 Nov;
43(4):558-68.
PMID: 25398757
Perfluorooctanoic acid (PFOA) is a ubiquitous pollutant that causes liver toxicity in rodents, a process believed to be dependent on peroxisome proliferator-activated receptor-alpha (PPARα) activation. Differences between humans and rodents...
4.
Thoolen B, Maronpot R, Harada T, Nyska A, Rousseaux C, Nolte T, et al.
Toxicol Pathol
. 2010 Dec;
38(7 Suppl):5S-81S.
PMID: 21191096
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great...
5.
Yoshizawa K, Walker N, Nyska A, Kissling G, Jokinen M, Brix A, et al.
Toxicol Pathol
. 2010 Oct;
38(7):1037-50.
PMID: 20924081
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally-similar dioxin-like compounds affect thyroid function and morphology and thyroid hormone metabolism in animals and humans. The National Toxicology Program conducted eight 2-year gavage studies in female...
6.
Yoshizawa K, Brix A, Sells D, Jokinen M, Wyde M, Orzech D, et al.
Toxicol Pathol
. 2009 Oct;
37(7):921-37.
PMID: 19843953
Results from previously published animal studies suggest that prenatal and postnatal exposure to dioxin and dioxin-like compounds (DLCs) may profoundly affect the reproductive system of both sexes via endocrine disruption....
7.
Dixon D, Herbert R, Kissling G, Brix A, Miller R, Maronpot R
Toxicol Pathol
. 2008 Apr;
36(3):428-39.
PMID: 18441259
The lung is the second most common target site of neoplasia of chemicals tested by the National Toxicology Program (NTP). Of all peer-reviewed NTP studies to date (N = 545),...
8.
Walker N, Yoshizawa K, Miller R, Brix A, Sells D, Jokinen M, et al.
Toxicol Pathol
. 2007 Dec;
35(7):880-9.
PMID: 18098034
Dioxin and dioxin-related compounds have been associated with high incidences of pulmonary dysfunctions and/or cancers in humans. To evaluate the relative potencies of effects of these compounds, the National Toxicology...
9.
Sells D, Brix A, Nyska A, Jokinen M, Orzech D, Walker N
Toxicol Pathol
. 2007 Feb;
35(1):170-7.
PMID: 17325986
This paper reviews respiratory tract lesions observed in rodents administered various chemicals by noninhalation routes. Chemicals administered by inhalation caused lesions in the respiratory tract and were well described; however,...
10.
Brix A, Nyska A, Haseman J, Sells D, Jokinen M, Walker N
Toxicol Pathol
. 2005 Jul;
33(4):477-83.
PMID: 16036865
The NTP has a long history of using Fischer rats and has compiled a large database of incidences of lesions seen in control animals. Such a database is lacking for...