Amudhan Venkateswaran
Overview
Explore the profile of Amudhan Venkateswaran including associated specialties, affiliations and a list of published articles.
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10
Citations
485
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Recent Articles
1.
Sekhar K, Benamar M, Venkateswaran A, Sasi S, Penthala N, Crooks P, et al.
Int J Radiat Oncol Biol Phys
. 2014 Jul;
89(5):1106-1114.
PMID: 25035215
Purpose: To test the hypothesis that small molecule targeting of nucleophosmin 1 (NPM1) represents a rational approach for radiosensitization. Methods And Materials: Wilde-type and NPM1-deficient mouse embryo fibroblasts (MEFs) were...
2.
Venkateswaran A, Sekhar K, Levic D, Melville D, Clark T, Rybski W, et al.
Cancer Res
. 2013 Nov;
74(1):38-43.
PMID: 24247717
ENOX1 is a highly conserved NADH oxidase that helps to regulate intracellular nicotinamide adenine dinucleotide levels in many cell types, including endothelial cells. Pharmacologic and RNA interference (RNAi)-mediated suppression of...
3.
Venkateswaran A, Friedman D, Walsh A, Skala M, Sasi S, Rachakonda G, et al.
Invest New Drugs
. 2012 Oct;
31(3):535-44.
PMID: 23054211
Targeting tumor vasculature represents a rational strategy for controlling cancer. (Z)-(+/-)-2-(1-benzylindol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol (denoted VJ115) is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule...
4.
Sekhar K, Reddy Y, Reddy P, Crooks P, Venkateswaran A, McDonald W, et al.
Clin Cancer Res
. 2011 Sep;
17(20):6490-9.
PMID: 21878537
Purpose: Radiation therapy continues to be an important therapeutic strategy for providing definitive local/regional control of human cancer. However, oncogenes that harbor driver mutations and/or amplifications can compromise therapeutic efficacy....
5.
Venkateswaran A, Thirupathi Reddy Y, Sonar V, Muthusamy V, Crooks P, Freeman M, et al.
Bioorg Med Chem Lett
. 2010 Nov;
20(24):7323-6.
PMID: 21055930
In the past half century research efforts have defined a critical role for angiogenesis in tumor growth and metastasis. We previously reported that inhibition of a novel target, ENOX1, by...
6.
Miller L, Mosher J, Venkateswaran A, Yang Z, Palumbo A, Phelps T, et al.
BMC Microbiol
. 2010 May;
10:149.
PMID: 20497531
Background: Communities of microorganisms control the rates of key biogeochemical cycles, and are important for biotechnology, bioremediation, and industrial microbiological processes. For this reason, we constructed a model microbial community...
7.
Ghosal D, Omelchenko M, Gaidamakova E, Matrosova V, Vasilenko A, Venkateswaran A, et al.
FEMS Microbiol Rev
. 2005 Apr;
29(2):361-75.
PMID: 15808748
We have recently shown that Deinococcus radiodurans and other radiation resistant bacteria accumulate exceptionally high intracellular manganese and low iron levels. In comparison, the dissimilatory metal-reducing bacterium Shewanella oneidensis accumulates...
8.
Brim H, Venkateswaran A, Kostandarithes H, Fredrickson J, Daly M
Appl Environ Microbiol
. 2003 Aug;
69(8):4575-82.
PMID: 12902245
Deinococcus geothermalis is an extremely radiation-resistant thermophilic bacterium closely related to the mesophile Deinococcus radiodurans, which is being engineered for in situ bioremediation of radioactive wastes. We report that D....
9.
Liu Y, Zhou J, Omelchenko M, Beliaev A, Venkateswaran A, Stair J, et al.
Proc Natl Acad Sci U S A
. 2003 Mar;
100(7):4191-6.
PMID: 12651953
Deinococcus radiodurans R1 (DEIRA) is a bacterium best known for its extreme resistance to the lethal effects of ionizing radiation, but the molecular mechanisms underlying this phenotype remain poorly understood....
10.
Lipton M, Pasa-Tolic L, Anderson G, Anderson D, Auberry D, Battista J, et al.
Proc Natl Acad Sci U S A
. 2002 Aug;
99(17):11049-54.
PMID: 12177431
Understanding biological systems and the roles of their constituents is facilitated by the ability to make quantitative, sensitive, and comprehensive measurements of how their proteome changes, e.g., in response to...