Amit V Desai
Overview
Explore the profile of Amit V Desai including associated specialties, affiliations and a list of published articles.
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18
Citations
216
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Recent Articles
1.
Kovanda L, Sullivan S, Smith L, Desai A, Bonate P, Hope W
Antimicrob Agents Chemother
. 2019 Apr;
63(6).
PMID: 30988142
VL-2397, a novel, systemic antifungal agent, has potent and fungicidal activity against species. Plasma concentrations from a phase 1 study were used to construct a population pharmacokinetic (PPK) model for...
2.
Desai A, Han D, Kowalski D, Lademacher C, Pearlman H, Yamazaki T
Antimicrob Agents Chemother
. 2019 Apr;
63(6).
PMID: 30962330
This phase 1, open-label, single-dose, parallel-group study evaluated the pharmacokinetics (PK) of isavuconazole after a single oral dose of the prodrug isavuconazonium sulfate in healthy nonelderly (age, 18 to 45 ...
3.
Kovanda L, Walsh T, Benjamin Jr D, Arrieta A, Kaufman D, Smith P, et al.
Pediatr Infect Dis J
. 2018 May;
37(6):580-585.
PMID: 29762386
Background: Neonatal candidiasis causes significant morbidity and mortality in high risk infants. The micafungin dosage regimen of 10 mg/kg established for the treatment of neonatal candidiasis is based on a...
4.
Desai A, Kovanda L, Hope W, Andes D, Mouton J, Kowalski D, et al.
Antimicrob Agents Chemother
. 2017 Sep;
61(12).
PMID: 28923872
Isavuconazole, the active moiety of the water-soluble prodrug isavuconazonium sulfate, is a triazole antifungal agent for the treatment of invasive fungal infections. The purpose of this analysis was to characterize...
5.
Kovanda L, Marty F, Maertens J, Desai A, Lademacher C, Engelhardt M, et al.
Antimicrob Agents Chemother
. 2017 Mar;
61(6).
PMID: 28289034
Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral...
6.
Townsend R, Akhtar S, Alcorn H, Berg J, Kowalski D, Mujais S, et al.
Eur J Clin Pharmacol
. 2017 Mar;
73(6):669-678.
PMID: 28271239
Purpose: The purpose of the study is to evaluate the effect of renal impairment (RI) and end-stage renal disease (ESRD) on the pharmacokinetics (PK) of isavuconazole and the inactive cleavage...
7.
Crofts A, Rose S, Burton R, Desai A, Kenis P, Dikanov S
J Phys Chem B
. 2017 Mar;
121(15):3701-3717.
PMID: 28241731
The Q-cycle mechanism of the bc complex is now well enough understood to allow application of advanced computational approaches to the study of atomistic processes. In addition to the main...
8.
Kovanda L, Desai A, Hope W
J Pharmacokinet Pharmacodyn
. 2017 Feb;
44(2):143-151.
PMID: 28181136
Galactomannan (GM) is a polysaccharide present in the cell wall of Aspergillus spp. that is released during growth of the organism. It has been successfully used to aide in the...
9.
Whittenberg J, Li H, Zhou H, Koziol J, Desai A, Reichert D, et al.
Bioconjug Chem
. 2017 Jan;
28(4):986-994.
PMID: 28085254
There is a growing demand for diagnostic procedures including in vivo tumor imaging. Radiometal-based imaging agents are advantageous for tumor imaging because radiometals (i) have a wide range of half-lives...
10.
Kovanda L, Desai A, Lu Q, Townsend R, Akhtar S, Bonate P, et al.
Antimicrob Agents Chemother
. 2016 May;
60(8):4568-76.
PMID: 27185799
Isavuconazonium sulfate (Cresemba; Astellas Pharma Inc.), a water-soluble prodrug of the triazole antifungal agent isavuconazole, is available for the treatment of invasive aspergillosis (IA) and invasive mucormycosis. A population pharmacokinetic...