Amit D Gujar
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Explore the profile of Amit D Gujar including associated specialties, affiliations and a list of published articles.
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16
Citations
967
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Recent Articles
1.
Yi E, Gujar A, Zhao D, Suina K, Jin X, Pardon K, et al.
bioRxiv
. 2025 Mar;
PMID: 40060579
Dear Editor Extrachromosomal DNA (ecDNA), a major focal oncogene amplification mode found across cancer, has recently regained attention as an emerging cancer hallmark , with a pervasive presence across cancers...
2.
Yi E, Gujar A, Guthrie M, Kim H, Zhao D, Johnson K, et al.
Cancer Discov
. 2021 Nov;
12(2):468-483.
PMID: 34819316
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across...
3.
Mahlokozera T, Patel B, Chen H, DeSouza P, Qu X, Mao D, et al.
Nat Commun
. 2021 Nov;
12(1):6321.
PMID: 34732716
The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2...
4.
Johnson K, Anderson K, Courtois E, Gujar A, Barthel F, Varn F, et al.
Nat Genet
. 2021 Oct;
53(10):1456-1468.
PMID: 34594038
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH...
5.
Zhu Y, Gujar A, Wong C, Tjong H, Ngan C, Gong L, et al.
Cancer Cell
. 2021 Apr;
39(5):694-707.e7.
PMID: 33836152
Extrachromosomal, circular DNA (ecDNA) is emerging as a prevalent yet less characterized oncogenic alteration in cancer genomes. We leverage ChIA-PET and ChIA-Drop chromatin interaction assays to characterize genome-wide ecDNA-mediated chromatin...
6.
Kim H, Nguyen N, Turner K, Wu S, Gujar A, Luebeck J, et al.
Nat Genet
. 2020 Aug;
52(9):891-897.
PMID: 32807987
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution; however, its frequency and clinical impact are unclear. Using computational analysis of whole-genome sequencing data from 3,212 cancer...
7.
Gujar A, Mao D, Finlay J, Kim A
Methods Mol Biol
. 2018 Feb;
1741:53-62.
PMID: 29392689
This chapter describes a method for isolation, maintenance, and propagation of primary glioblastoma (GBM) cells in adherent monolayer cultures from patient tumor specimens. This method enables the establishment of GBM...
8.
Huang J, Campian J, Gujar A, Tsien C, Ansstas G, Tran D, et al.
J Neurooncol
. 2018 Jan;
138(1):105-111.
PMID: 29374809
Disulfiram has shown promising activity including proteasome inhibitory properties and synergy with temozolomide in preclinical glioblastoma (GBM) models. In a phase I study for newly diagnosed GBM after chemoradiotherapy, we...
9.
Gujar A, Le S, Mao D, Dadey D, Turski A, Sasaki Y, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(51):E8247-E8256.
PMID: 27930300
Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD). Nevertheless, how the regulation of this metabolic cofactor interfaces with signal transduction networks...
10.
Gujar A, Yano H, Kim A
Mol Cell Oncol
. 2016 Jun;
3(3):e1075644.
PMID: 27314081
Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20-anaphase-promoting complex...