Amit Choudhary
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Explore the profile of Amit Choudhary including associated specialties, affiliations and a list of published articles.
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1252
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Recent Articles
11.
Gibson W, Sadagopan A, Shoba V, Choudhary A, Meyerson M, Schreiber S
bioRxiv
. 2023 Jul;
PMID: 37461636
The aberrant localization of proteins in cells is a key factor in the development of various diseases, including cancer and neurodegenerative disease. To better understand and potentially manipulate protein localization...
12.
Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu K, et al.
Cell Metab
. 2023 Jun;
35(7):1242-1260.e9.
PMID: 37339634
Type 1 (T1D) or type 2 diabetes (T2D) are caused by a deficit of functional insulin-producing β cells. Thus, the identification of β cell trophic agents could allow the development...
13.
Sahay A, Epari S, Chinnaswamy G, Chatterjee A, Goda J, Patil V, et al.
Neurol India
. 2023 Jun;
71(3):500-508.
PMID: 37322747
Background And Objective: Primary intracranial germ cell tumors (ICGCTs) are rare and are histologically classified as germinomas and non-germinomatous with distinctive prognostic and therapeutic implications. ICGCTs, essentially due to the...
14.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
Cell Metab
. 2023 Apr;
35(5):887-905.e11.
PMID: 37075753
Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated diseases. However, there are no scalable approaches to comprehensively assess the diverse FFAs circulating in human...
15.
Arp C, Reynders M, Sreekanth V, Kokkonda P, Pagano M, Choudhary A, et al.
bioRxiv
. 2023 Apr;
PMID: 37066279
Immunomodulatory drugs (IMiDs), which include thalidomide and its derivatives, have emerged as the standard of care against multiple myeloma. They function as molecular glues that bind to the E3 ligase...
16.
Sreekanth V, Jan M, Zhao K, Lim D, Davis J, McConkey M, et al.
bioRxiv
. 2023 Mar;
PMID: 36945568
Cas9 is a programmable nuclease that has furnished transformative technologies, including base editors and transcription modulators (e.g., CRISPRi/a), but several applications of these technologies, including therapeutics, mandatorily require precision control...
17.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865221
Highlights: FALCON (Fatty Acid Library for Comprehensive ONtologies) enables multimodal profiling of 61 free fatty acids (FFAs) to reveal 5 FFA clusters with distinct biological effectsFALCON is applicable to many...
18.
Choudhary A, Ahlawat S, Urooj S, Pathak N, Lay-Ekuakille A, Sharma N
Healthcare (Basel)
. 2023 Jan;
11(2).
PMID: 36673578
This study addresses the problem of the automatic detection of disease states of the retina. In order to solve the abovementioned problem, this study develops an artificially intelligent model. The...
19.
Lim D, Zhou Q, Cox K, Law B, Lee M, Kokkonda P, et al.
Nat Cell Biol
. 2022 Nov;
24(12):1766-1775.
PMID: 36396978
The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present are not...
20.
Shoba V, Munkanatta Godage D, Chaudhary S, Deb A, Siriwardena S, Choudhary A
Angew Chem Int Ed Engl
. 2022 May;
61(29):e202202770.
PMID: 35641438
Phosphorylation-inducing chimeric small molecules (PHICS) can enable a kinase to act at a new cellular location or phosphorylate non-native substrates (neo-substrates)/ sites (neo-phosphorylations). We report a modular design and high-yielding...