Amirhossein Sakhteman
Overview
Explore the profile of Amirhossein Sakhteman including associated specialties, affiliations and a list of published articles.
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70
Citations
374
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Recent Articles
1.
Hofer S, Frasch L, Brajkovic S, Putzker K, Lewis J, Schurmann H, et al.
Mol Syst Biol
. 2025 Jan;
21(3):231-253.
PMID: 39838187
The DNA-damaging agent Gemcitabine (GEM) is a first-line treatment for pancreatic cancer, but chemoresistance is frequently observed. Several clinical trials investigate the efficacy of GEM in combination with targeted drugs,...
2.
Baziar L, Emami L, Rezaei Z, Solhjoo A, Sakhteman A, Khabnadideh S
Sci Rep
. 2024 Nov;
14(1):26538.
PMID: 39489787
A novel series of 4-aminopiperidin-3,4-dihyroquinazoline-2-uracil derivatives (9a-9 L) were logically designed and synthesized as potent DPP4 inhibitors as antidiabetic agents. Chemical structure of all new compounds were confirmed by different...
3.
Kabiri M, Hajizade M, Zarei M, Eskandari S, Sakhteman A, Khoshneviszadeh M
Chem Biodivers
. 2024 Aug;
21(12):e202401035.
PMID: 39143024
Tyrosinase, a metalloprotein enzyme, plays a crucial role in melanin synthesis by hydroxylating L-tyrosine to L-dopa. However, the accumulation of melanin can lead to hyperpigmented spots, raising aesthetic concerns. In...
4.
Mohammad Ali F, Zare F, Sakhteman A, Bahadori S, Seradj H, Emami L
Nat Prod Res
. 2024 Jul;
:1-11.
PMID: 39049514
Inflammation is an immune system response triggered by pathogens, damaged cells, or stimuli. Some regulatory enzymes, such as phosphodiesterase, hyaluronidase, collagenase, and lipoxygenase, play an essential role in the inflammatory...
5.
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Chang Y, Gnann C, Steimbach R, Bayer F, Lechner S, Sakhteman A, et al.
Cell Rep
. 2024 May;
43(6):114272.
PMID: 38795348
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action...
6.
Eckert S, Berner N, Kramer K, Schneider A, Muller J, Lechner S, et al.
Nat Biotechnol
. 2024 May;
PMID: 38714896
Proteomics is making important contributions to drug discovery, from target deconvolution to mechanism of action (MoA) elucidation and the identification of biomarkers of drug response. Here we introduce decryptE, a...
7.
Zare F, Ataollahi E, Mardaneh P, Sakhteman A, Keshavarz V, Solhjoo A, et al.
Sci Rep
. 2024 Apr;
14(1):7749.
PMID: 38565703
DPP4 inhibitors can control glucose homeostasis by increasing the level of GLP-1 incretins hormone due to dipeptidase mimicking. Despite the potent effects of DPP4 inhibitors, these compounds cause unwanted toxicity...
8.
Farahmandnejad M, Mosaddeghi P, Dorvash M, Sakhteman A, Negahdaripour M, Faridi P
Biomedicines
. 2024 Feb;
12(2).
PMID: 38397917
Some studies have investigated the potential role of transposable elements (TEs) in COVID-19 pathogenesis and complications. However, to the best of our knowledge, there is no study to examine the...
9.
Lee C, The M, Meng C, Bayer F, Putzker K, Muller J, et al.
Mol Syst Biol
. 2024 Jan;
20(1):28-55.
PMID: 38177929
Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the...
10.
Tushaus J, Sakhteman A, Lechner S, The M, Mucha E, Krisp C, et al.
EMBO J
. 2023 Nov;
42(23):e114665.
PMID: 37916885
Substantial efforts are underway to deepen our understanding of human brain morphology, structure, and function using high-resolution imaging as well as high-content molecular profiling technologies. The current work adds to...