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Ambuj K Singh

Explore the profile of Ambuj K Singh including associated specialties, affiliations and a list of published articles. Areas
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Articles 29
Citations 223
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Recent Articles
11.
Ranu S, Singh A
J Chem Inf Model . 2011 Apr; 51(5):1106-21. PMID: 21488651
We propose a novel method for pharmacophore analysis by examining the Joint Pharmacophore Space of chemical compounds, targets, and chemical/biological properties. The proposed approach is a notable deviation from existing...
12.
Chipman K, Singh A
BMC Bioinformatics . 2011 Jan; 12:7. PMID: 21211042
Background: The combination of genotypic and genome-wide expression data arising from segregating populations offers an unprecedented opportunity to model and dissect complex phenotypes. The immense potential offered by these data...
13.
Bogdanov P, Singh A
IEEE/ACM Trans Comput Biol Bioinform . 2010 May; 7(2):208-17. PMID: 20431141
The recent advent of high-throughput methods has generated large amounts of gene interaction data. This has allowed the construction of genomewide networks. A significant number of genes in such networks...
14.
Camoglu O, Can T, Singh A
Adv Bioinformatics . 2010 Feb; :787128. PMID: 20182643
A protein network shows physical interactions as well as functional associations. An important usage of such networks is to discover unknown members of partially known complexes and pathways. A number...
15.
Ranu S, Singh A
J Chem Inf Model . 2009 Nov; 49(11):2537-50. PMID: 19928835
The increased availability of large repositories of chemical compounds has created new challenges in designing efficient molecular querying and mining systems. Molecular classification is an important problem in drug development...
16.
Macropol K, Can T, Singh A
BMC Bioinformatics . 2009 Sep; 10:283. PMID: 19740439
Background: We propose an efficient and biologically sensitive algorithm based on repeated random walks (RRW) for discovering functional modules, e.g., complexes and pathways, within large-scale protein networks. Compared to existing...
17.
Chipman K, Singh A
BMC Bioinformatics . 2009 Jan; 10:17. PMID: 19138426
Background: Several studies have demonstrated that synthetic lethal genetic interactions between gene mutations provide an indication of functional redundancy between molecular complexes and pathways. These observations help explain the finding...
18.
LeBoeuf A, Levy S, Gaylord M, Bhattacharya A, Singh A, Jordan M, et al.
J Biol Chem . 2008 Oct; 283(52):36406-15. PMID: 18940799
Mutations affecting either the structure or regulation of the microtubule-associated protein Tau cause neuronal cell death and dementia. However, the molecular mechanisms mediating these deleterious effects remain unclear. Among the...
19.
Bhattacharya A, Levy S, LeBoeuf A, Gaylord M, Wilson L, Singh A, et al.
BMC Bioinformatics . 2008 Aug; 9:339. PMID: 18700022
Background: Innumerable biological investigations require comparing collections of molecules, cells or organisms to one another with respect to one or more of their properties. Almost all of these comparisons are...
20.
Larusso N, Ruttenberg B, Singh A, Oakley T
J Mol Evol . 2008 Apr; 66(5):417-23. PMID: 18392762
Opsins are a large group of proteins with seven transmembrane segments (TMSs) that are found in all domains of life. There are two types of opsins that are sometimes considered...