Amanda McFedries
Overview
Explore the profile of Amanda McFedries including associated specialties, affiliations and a list of published articles.
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5
Citations
287
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Recent Articles
1.
Johnson L, Barrick S, Hager M, McFedries A, Homan E, Rabaglia M, et al.
J Am Chem Soc
. 2014 Sep;
136(37):12848-51.
PMID: 25191938
Glucagon-like peptide-1 (GLP-1) is a natural agonist for GLP-1R, a G protein-coupled receptor (GPCR) on the surface of pancreatic β cells. GLP-1R agoinsts are attractive for treatment of type 2...
2.
Maianti J, McFedries A, Foda Z, Kleiner R, Du X, Leissring M, et al.
Nature
. 2014 May;
511(7507):94-8.
PMID: 24847884
Despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of IDE (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between the activity...
3.
Lopez-Sagaseta J, Dulberger C, McFedries A, Cushman M, Saghatelian A, Adams E
J Immunol
. 2013 Oct;
191(10):5268-77.
PMID: 24108697
MR1-restricted mucosal-associated invariant T (MAIT) cells represent a subpopulation of αβ T cells with innate-like properties and limited TCR diversity. MAIT cells are of interest because of their reactivity against...
4.
McFedries A, Schwaid A, Saghatelian A
Chem Biol
. 2013 May;
20(5):667-73.
PMID: 23706633
Understanding the interactions between small molecules and proteins can be approached from different perspectives and is important for the advancement of basic science and drug development. Chemists often use bioactive...
5.
Lopez-Sagaseta J, Dulberger C, Crooks J, Parks C, Luoma A, McFedries A, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(19):E1771-8.
PMID: 23613577
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved αβ T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the MHC related-1 (MR1) protein. MAIT cells are dependent...