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» Authors » Alyssa Birt

Alyssa Birt

Explore the profile of Alyssa Birt including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 90
Followers 0
Related Specialties
Biology
Reproductive Medicine
General Medicine
Top 10 Co-Authors
Paul D Rennert
Lan Wu
Lihe Su
Roy R Lobb
Christine Ambrose
Fay J Dufort
Benjamin J Hackel
Troy L Ott
Koryu Kin
Sreelakshmi Vasudevan
Published In
Reprod Biol Endocrinol
Mol Pharm
Nat Commun
Biol Reprod
PLoS One
Affiliations
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Recent Articles
1.
Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models
Yang Y, Yang H, Alcaina Y, Puc J, Birt A, Vedvyas Y, et al.
Nat Commun . 2023 Apr; 14(1):2068. PMID: 37045815
The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies....
2.
Anti-CD19 CAR T Cells That Secrete a Biparatopic Anti-CLEC12A Bridging Protein Have Potent Activity Against Highly Aggressive Acute Myeloid Leukemia and
Rennert P, Dufort F, Su L, Sanford T, Birt A, Wu L, et al.
Mol Cancer Ther . 2021 Jul; 20(10):2071-2081. PMID: 34253594
Refractory acute myeloid leukemia (AML) remains an incurable malignancy despite the clinical use of novel targeted therapies, new antibody-based therapies, and cellular therapeutics. Here, we describe the preclinical development of...
3.
Anti-CD19 CAR T cells potently redirected to kill solid tumor cells
Ambrose C, Su L, Wu L, Dufort F, Sanford T, Birt A, et al.
PLoS One . 2021 Mar; 16(3):e0247701. PMID: 33735268
Successful CAR T cell therapy for the treatment of solid tumors requires exemplary CAR T cell expansion, persistence and fitness, and the ability to target tumor antigens safely. Here we...
4.
Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins
Klesmith J, Su L, Wu L, Schrack I, Dufort F, Birt A, et al.
Mol Pharm . 2019 Jun; 16(8):3544-3558. PMID: 31242389
CD19-targeted chimeric antigen receptor (CAR) T-cells (CAR19s) show remarkable efficacy in the treatment of relapsed/refractory acute lymphocytic leukemia and Non-Hodgkin's lymphoma. However, the use of CAR T-cell therapy against CD19-negative...
5.
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts
Kin K, Maziarz J, Chavan A, Kamat M, Vasudevan S, Birt A, et al.
Genome Biol Evol . 2016 Jul; 8(8):2459-73. PMID: 27401177
The endometrial stromal fibroblast (ESF) is a cell type present in the uterine lining of therian mammals. In the stem lineage of eutherian mammals, ESF acquired the ability to differentiate...
6.
Low doses of bovine somatotropin enhance conceptus development and fertility in lactating dairy cows
Ribeiro E, Bruno R, Farias A, Hernandez-Rivera J, Gomes G, Surjus R, et al.
Biol Reprod . 2013 Nov; 90(1):10. PMID: 24285716
Objectives were to evaluate the effects of administering either one or two low doses of slow-release recombinant bovine somatotropin (bST) on hormone concentrations, conceptus development, and fertility in dairy cows....
7.
Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines
Duncan A, Forcina J, Birt A, Townson D
Reprod Biol Endocrinol . 2012 Nov; 10:90. PMID: 23113883
Background: Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression. In certain cell-types, sensitivity to these death-inducing...