Alysia R Bryll
Overview
Explore the profile of Alysia R Bryll including associated specialties, affiliations and a list of published articles.
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5
Citations
285
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0
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Recent Articles
1.
Chio U, Rechiche O, Bryll A, Zhu J, Leith E, Feldman J, et al.
Sci Adv
. 2023 Apr;
9(15):eadf7586.
PMID: 37058572
Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 removes acetyl groups from histone...
2.
Chio U, Rechiche O, Bryll A, Zhu J, Feldman J, Peterson C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993468
Teaser: The structure of the SIRT6 deacetylase/nucleosome complex suggests how the enzyme acts on both histone H3 K9 and K56 residues.
3.
Bryll A, Peterson C
Transcription
. 2023 Feb;
14(1-2):18-26.
PMID: 36843061
Eukaryotic cells rely upon dynamic, multifaceted regulation at each step of RNA biogenesis to maintain mRNA pools and ensure normal protein synthesis. Studies in budding yeast indicate a buffering phenomenon...
4.
Bryll A, Peterson C
Genes Dev
. 2021 Dec;
36(1-2):17-22.
PMID: 34916303
Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation of the RNA exosome leads to global reduction of...
5.
Flynn R, Cox K, Jeitany M, Wakimoto H, Bryll A, Ganem N, et al.
Science
. 2015 Jan;
347(6219):273-7.
PMID: 25593184
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human...