Functional Interaction Between the RNA Exosome and the Sirtuin Deacetylase Hst3 Maintains Transcriptional Homeostasis

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2021 Dec 17

PMID 34916303

Citations 5

Authors

Alysia R Bryll

Craig L Peterson

Affiliations

Soon will be listed here.

Abstract

Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation of the RNA exosome leads to global reduction of nascent mRNA transcripts, and that this defect is accentuated by loss of deposition of histone variant H2A.Z. We identify the mRNA for the sirtuin deacetylase Hst3 as a key target for the RNA exosome that mediates communication between RNA degradation and transcription machineries. These findings reveal how the RNA exosome and H2A.Z function together to control a deacetylase, ensuring proper levels of transcription in response to changes in RNA degradation.

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