Alyna T Khan
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Explore the profile of Alyna T Khan including associated specialties, affiliations and a list of published articles.
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13
Citations
274
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Recent Articles
1.
Iyer K, Clarke S, Guarischi-Sousa R, Gjoni K, Heath A, Young E, et al.
J Am Heart Assoc
. 2025 Feb;
14(4):e036499.
PMID: 39950338
Background: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics...
2.
Rocheleau G, Clarke S, Auguste G, Hasbani N, Morrison A, Heath A, et al.
Nat Commun
. 2024 Oct;
15(1):8741.
PMID: 39384761
Whole genome sequences (WGS) enable discovery of rare variants which may contribute to missing heritability of coronary artery disease (CAD). To measure their contribution, we apply the GREML-LDMS-I approach to...
3.
Georgakis M, Malik R, El Bounkari O, Hasbani N, Li J, Huffman J, et al.
medRxiv
. 2023 Aug;
PMID: 37645892
Background: Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides...
4.
Stergachis A, Blue E, Gillentine M, Wang L, Schwarze U, Cortes A, et al.
Neurol Genet
. 2023 Aug;
9(5):e200090.
PMID: 37560121
Objectives: Transcript sequencing of patient-derived samples has been shown to improve the diagnostic yield for solving cases of suspected Mendelian conditions, yet the added benefit of full-length long-read transcript sequencing...
5.
Aalbers S, Khan A, Weir B
Forensic Sci Int Synerg
. 2023 Jun;
6:100335.
PMID: 37325613
With the introduction of next generation sequencing (NGS) technology in the forensic field, it will be of interest to assess if forensic scientists feel equipped to interpret and present DNA...
6.
Kurniansyah N, Goodman M, Khan A, Wang J, Feofanova E, Bis J, et al.
Nat Commun
. 2023 Jun;
14(1):3202.
PMID: 37268629
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct...
7.
Stergachis A, Blue E, Gillentine M, Wang L, Schwarze U, Cortes A, et al.
bioRxiv
. 2023 Feb;
PMID: 36798371
Objectives: Transcript sequencing of patient derived samples has been shown to improve the diagnostic yield for solving cases of likely Mendelian disorders, yet the added benefit of full-length long-read transcript...
8.
Khan A, Gogarten S, McHugh C, Stilp A, Sofer T, Bowers M, et al.
Cell Genom
. 2022 Sep;
2(8).
PMID: 36119389
How race, ethnicity, and ancestry are used in genomic research has wide-ranging implications for how research is translated into clinical care and incorporated into public understanding. Correlation between race and...
9.
Kelly T, Sun X, He K, Brown M, Gagliano Taliun S, Hellwege J, et al.
Hypertension
. 2022 Jun;
79(8):1656-1667.
PMID: 35652341
Background: The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure....
10.
Nakao T, Bick A, Taub M, Zekavat S, Uddin M, Niroula A, et al.
Sci Adv
. 2022 Apr;
8(14):eabl6579.
PMID: 35385311
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of...